In this work, we report a nature indefinite permittivity in crystalline graphite that exhibits negative group refraction at ultraviolet region. A hyperbolic equifrequency contour was obtained from ellipsometry data at 254 nm and an all angle negative refraction was verified experimentally. The indefinite permittivity is attributed to extremely strong anisotropy in the crystal structure and the hybrid electronic transitions. This result not only explores a route toward natural negative-index materials, but also holds a promise for ultraviolet hyperlens, which may lead to a breakthrough in nanolithography for the next generation of electronics.

A surface plasmon resonance (SPR)-surface enhanced Raman scattering (SERS) microspectrometer was designed to obtain the incident angle dependence of SERS signals excited by the evanescent field. By simultaneous measurement of the SERS and SPR spectra of analytes, the highest SERS signal intensities were found to appear at the vicinity of the resonance angle. The enhancement factor was about 2.0x10(6). The simulated angle of the maximal SERS intensity based on Fresnel equation was found to be in good agreement with the experimental results. The SERS and SPR spectra captured simultaneously not only directly confirm the correlation between the SERS and SPR but also present a potential technique for obtaining the structure information about the analytes in molecule level with recording their SPR curves.

ZnS:Mn has been in-filled in photonic crystals of submicron polymer spheres. The effect of the photonic band gap on the photoluminescence (PL) properties of ZnS:Mn has been investigated. Because of the overlap of the transmission dip of the photonic crystal and the photoluminescence band of ZnS:Mn, both suppression and enhancement in the PL of the phosphor have been observed. A strong dependence of the fluorescence lifetime on the emission wavelength in the range of the stop band has been found. This strong dependence is believed to arise from the very low photon density of state within the stop band of the ZnS:Mn in-filled photonic crystal as result of a high dielectric contrast between ZnS:Mn and the polystyrene spheres.

The tunability of an omega-type left handed metamaterial was demonstrated at microwave frequencies via the magnetic control of liquid crystal (LC) orientation. From the experimental and simulation results, it is shown that the left handed pass-band can be tuned by 220 MHz by changing the orientation of LC molecules by 90 degrees. A maximum index variation of 0.25 was obtained in the negative index regime with a measured LC birefringence of 0.05 in the 10 - 12 GHz frequency band.

BackgroundUL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action.MethodsA HSV-1 UL7 mutant (UL7-MU) was constructed using the CRISPR-cas9 system. The replication rate and plaque morphology were used to analyze the biological characteristics of the wild-type (WT), UL7-MU and MU-complemented P1 viruses. The virulence of the viruses was evaluated in mice. Real-time RT-qPCR and ChIP assays were used to determine the expression levels of relevant genes.ResultsThe replication capacity of a recombinant virus (UL7-MU strain) was 10-fold lower than that of the WT strain. The neurovirulence and pathologic effect of the UL7-MU strain were attenuated in infected mice compared with the WT strain. In the latency model, the expression of latency-associated transcript (LAT) in the central nervous system (CNS) and trigeminal nerve was lower in UL7-MU-infected mice than in WT strain-infected mice. The transcription level of the immediate-early gene α-4 in UL7-MU-infected cells was reduced by approximately 2-fold compared with the clear transcriptional peak identified in WT strain-infected Vero cells within 7 h post-infection (p.i.).ConclusionBy modulating the transcription of the α-4 gene, UL7 may be involved in transcriptional regulation through its interaction with the transcript complex structure of the viral genome during HSV-1 infection.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-016-0600-9) contains supplementary material, which is available to authorized users.