High-pressure is utilized to realize new 2D layered structures in PdSe2 with high-mobility transport anisotropy for photovoltaic applications.

The exact knowledge of helical carbon nanotube (HCNT) growth mechanism has not yet been completely clarified, and effective synthesis of high-purity helical carbon nanotubes in high yield still remains a tremendous challenge. In this study, HCNTs were synthesized via a catalytic chemical vapor deposition method using Fe nanoparticles as catalysts. We performed systematic experiments to investigate the specific effect of catalytic particle size (CPS) on the selective growth of HCNTs, such as on the morphology, yield, mobility of carbon atoms, and HCNT purity of carbon products. Our study showed that the CPS plays a key role in the selectivity to HCNTs, yield, and morphology of the carbon products, and a small catalytic particle is favorable to HCNT formation. We hope that this result may give a beneficial suggestion to obtain highly pure HCNTs. A CPS-dependent growth mechanism for HCNTs was finally proposed. Magnetic measurements demonstrated that the HCNTs are ferromagnetic properties and show high magnetization at room temperature.

We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this paper we describe an extensive structure–activity relationship study of this class of MDM2 inhibitors, which led to the discovery of 60 (AA-115/APG-115). Compound 60 has a very high affinity to MDM2 (Ki < 1 nM), potent cellular activity, and an excellent oral pharmacokinetic profile. Compound 60 is capable of achieving complete and long-lasting tumor regression in vivo and is currently in phase I clinical trials for cancer treatment.

Rapid advances in functional electronics bring tremendous demands on innovation toward effective designs of device structures. Yarn supercapacitors (SCs) show advantages of flexibility, knittability, and small size, and can be integrated into various electronic devices with low cost and high efficiency for energy storage. In this work, functionalized stainless steel yarns are developed to support active materials of positive and negative electrodes, which not only enhance capacitance of both electrodes but can also be designed into stretchable configurations. The as-made asymmetric yarn SCs show a high energy density of 0.0487 mWh cm (10.19 mWh cm ) at a power density of 0.553 mW cm (129.1 mW cm ) and a specific capacitance of 127.2 mF cm under an operating voltage window of 1.7 V. The fabricated SC is then made into a stretchable configuration by a prestraining-then-releasing approach using polydimethylsiloxane (PDMS) tube, and its electrochemical performance can be well maintained when stretching up to a high strain of 100%. Moreover, the stretchable cable-type SCs are stably workable under water-immersed condition. The method opens up new ways for fabricating flexible, stretchable, and waterproof devices.