The Moon-based Ground Penetrating Radar (GPR) 1 carried by the Yutu rover performed in-situ radar measurements 2 to explore extraterrestrial objects, which provides an unprece-3 dented opportunity to study the shallow subsurface structure of 4 the Moon and its internal resources. Exploiting lunar resources 5 might be one of the solutions to the Earth's energy shortage 6 in the future. In this paper, firstly, the thickness distribution of 7 the lunar regolith at the Chang'E-3 landing site is derived using 8 the high-frequency Yutu radar observation data. Secondly, the 9 surface concentration of helium-3 is determined based on the 10 surface TiO2 content of the lunar regolith. Finally, the reservoir 11 of helium-3 resources in the lunar regolith is estimated. Our 12 result suggests that the helium-3 reservoir along the Yutu rover 13 traveling route from the navigation points N105 to N208 (∼445 14 m 2 ) is ∼37-51 g, and its helium-3 content per unit area is 15 ∼0.083-0.114 g/m 2 , which is at least 5 times higher than that of 16 the global average. Currently, the nuclear fusion experiment is 17 facing a severe shortage of tritium fuel. We discuss the possibility 18 of replacing it with lunar helium-3 as the fuel for nuclear fusion. 19 Meanwhile, we also suggest that the Chang'E-3 landing area can 20 be a potential site selection for the exploitation of the lunar 21 helium-3 in the future. Our results will provide a valuable 22 reference to evaluate the economics and feasibility of mining 23 in-situ helium-3 resources on the Moon.

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