No abstract

Educational behavioral psychology refers to the fact that college students within campus networks have various psychological cognition toward novel information and behavior. This is hardly ever taken into account or theoretically examined in weighted network research. According to psychological traits and a student’s willingness to adopt fresh behaviors, we categorize students’ behaviors into the active and passive. On this basis, a threshold models is established for the behavior of active and passive students in weighted networks, and the influence behavioral psychology on information propagation is discussed. In order to qualitatively investigate the information propagation mechanism, a partition theory based on edge-weight and behavioral psychology is developed. Active students encourage the acceptance of new behaviors and the spread of information, according to theoretical study and simulation results. However, the phase transition intersected was more significant. When the percentage of enrolled pupils is high, a continuous phase transition is present in the growth pattern of the final adoption size. In contrast, as the proportion of active students declines, the increasing pattern alterss to discontinuous phase transition. In addition, weight distribution heterogeneity facilitates the dissemination of information and does not alter phase transition pattern. Finally, the theoretical analysis is in good agreement with the simulation results.

Background: Long-term antiretroviral therapy (ART) cannot recover the T cell counts in a substantial proportion of AIDS patients and viral loads rapidly rebound after ART suspension. Therefore, exploring novel alternative and adjuvant ART has become a priority in HIV treatment. Traditional Chinese medicine (TCM) have beneficial effects in regulating T cells and our previous clinical trial data have shown that TCM TN-01 maintains good health of patients with AIDS with an unclear mechanism. Herein, we preliminary investigated whether TN-01 influences immune reconstruction to enhance the antiviral immune response in simian immunodeficiency virus (SIV)-infected rhesus monkeys. Methods: The SIV-infected animals were firstly administered with TN-01 alone (5 ml/kg; twice a day, i.g.). More than 2 months later, these 2 SIV-infected rhesus monkeys were intraperitoneally injected with PMPA (30 mg/kg; once a day) and FTC (20 mg/kg; once a day) for about 3 months. Moreover, SIV-infected rhesus monkeys were also administered with TN-01 each 2 weeks from week 23 to week 35 during ART. Flow cytometer were used to assess the phenotype of T cell and plasma was isolated from whole blood for viral load detection. Results: The flow cytometry analysis revealed that treatment with TN-01 alone or combined with ART significantly upregulated T cells counts and the proportions of T cell subsets. TN-01 treatment also delayed viral rebound after ART suspension. Conclusions: Our data indicate that TN-01 could enhance the efficacy of ART and promote immune reconstruction, suggesting TN-01 treatment as a potent strategy in immune functional cure of HIV infection.