BACKGROUND Tuberculosis (TB) is an infectious disease caused by the organism Mycobacterium tuberculosis. It is one of the leading infectious causes of death worldwide. The aim of the study was to see the adverse drug reactions of the first line anti TB drugs in extr a pulmonary tuberculosis (EPTB) population. The aim of this study was to evaluate the adverse drug reactions to first line antituberculosis drugs in EPTB. MATERIALS AND METHODS The study was conducted in a tertiary care setting. It was a prospective, observational study. 60 patients suffering from EPTB were included. Patients were categorised to receive either category I, Category II DOTS or a private regimen. The data was analysed using SPSS version 20 software. Chi-square test were used for compared proportions. RESULTS Out of 60 patients, 22 (36.66%) developed ADR. The incidence of ADR's were found to be more in females (77.27%) as compared to males (22.72). Incidence of ADR's were maximum in the age group 21-40 years (63.63%). CONCLUSION A knowledge about ADR's is essential for effective management of any disease.