Polycystic ovary syndrome (PCOS), a common hormonal disorder in women of reproductive age, is associated with a poor and unhealthy diet. This study aimed to investigate the effect of a high sucrose and cholic acid (HSCA) diet in the presence of PCOS-like phenotypes. Female Wistar rats were divided into HSCA and normal diet groups for four weeks, each with twenty rats. Body weight was assessed before and after the study. Blood and fecal samples were obtained to measure HOMA-IR and testosterone level (ELISA) and Enterobacteriaceae isolates grown on MacConkey Agar. Obtained ovarian tissues were H&E-stained. HSCA rats demonstrated a reduction in Enterobacteriaceae colonies (median 4.75 × 105 vs. 2.47 × 104/CFU, p < 0.001) and an elevated HOMA-IR (mean 2.94 ± 1.30 vs. 4.92 ± 0.51, p < 0.001), as well as an increase in testosterone level (median 0.65 vs. 3.00 ng/mL, p < 0.001), despite no statistical differences in the change in body weight (mean −2.31 ± 14.42 vs. −3.45 ± 9.32, p = 0.769). In H&E staining, HSCA rats had a reduction in preovulatory follicle count (median 0.50 vs. 0.00, p = 0.005). The HSCA diet caused insulin resistance and high testosterone levels, which contribute to the development of PCOS, and affected folliculogenesis by altering follicular maturation, but had no effect on ovulation.

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Introduction: Infertility is one of the common clinical symptoms in women with endometriosis. Limited ways to diagnose endometriosis, symptoms of endometriosis considered normal and overlap with other diseases that cause delaying treatment that increase the duration of infertility. This study purpose to analyze the differences in duration of infertility to women with endometriosis and without endometriosis. Method: This study is observational analytical research with retrospective case-control designed by looking at medical records in Fertility Clinic Graha Amerta RSUD Dr. Soetomo Surabaya. Total samples in this research are 50 women with infertility, it is divided into 25 people with endometriosis and 25 people without endometriosis. In the medical records, we can see the duration of infertility in each sample. Results: The duration of infertility >3 years occurs in women with and without endometriosis (72% and 80%). In bivariate analysis using the chi-square test, there was no difference that showed increasing duration of infertility (P = 0.508) between women with endometriosis and without endometriosis. Conclusion: There was no differences in the duration of female infertility with endometriosis and without endometriosis

Background: Hemorrhagic shock is one of the most common types of shock in trauma patients, and it is defined as acute blood volume loss. One of the causes of hemorrhagic shock is post-childbirth bleeding or post-partum bleeding. The most important management for patients who experience post-partum bleeding is blood transfusions. Type-O blood is known as a universal donor, because someone with type- O blood can transfuse theirs to recipients with blood types other than O. Giving blood transfusions to pos-tpartum bleeding patients is expected to extend their life expectancy, however it cannot be denied that there are quite a several patients who died after receiving transfusions from universal type O blood.Objective: This study aims to determine the profile and effect of universal O use on hemorrhagic shock within post-partum bleeding patients at IGS RSUD Dr. Soetomo Surabaya.Methods: This research was conducted by a descriptive retrospective method by observing the patient's medical record data in the central medical record room of Dr. Soetomo Hospital, Surabaya.Result: There were 17 patients with hemorrhagic shock due to post-partum hemorrhage who received blood transfusions from universal O donors at Dr. Soetomo Surabaya. From the obtained data, the patient age group was dominated by the 28 years old group (23,5%). Transfusion history within patients with the most hemorrhagic shock due to post-partum bleeding were patients who received transfusions with packed red cell (PRC) O + (76,5%). As for transfusion reactions that occur within patients, there are no data on transfusion reactions.Conclusion: The 28 years old group was the largest one that received transfusions from the universal group O blood. History transfusion of hemorrhagic shock due to post-partum bleeding patients shows that most of them are those who received PRC O + transfusions. There are no data regarding the transfusion reactions which occurred in these patients.

Background: Dysmenorrhea is a symptom of pain experienced before or during menstruation. Based on literature review and previous research, the negative impact of basic education on adolescent girls has decreased quality of life by 80%. Good quality of life after experiencing primary dysmenorrhea with coping strategies and pain acceptance. This study aims to analyze the relationship between coping and acceptance with quality of life in adolescents with primary dysmenorrhea. Methods: This study uses analytical observational with a cross sectional approach. A sample of 43 students was obtained using simple random sampling at SMP PGRI Mekarmanik with the inclusion criteria of adolescent girls aged 13-16 years who had experienced menstruation in the last 3 months and experienced primary dysmenorrhea. Data collection was carried out online using a Google Form containing structured questionnaires WOC, CPAQ-8, WHO-QOLBRIEF and NPRS. Then analyze the data with Chi Square and Rank Spearman tests with a significance limit of 5%. Results: The percentage of respondents who experienced primary dysmenorrhea was 100% with the majority of moderate pain degrees 51.16%. There is no relationship between coping strategies and quality of life (p=0.897) because the majority of respondents use the EFC coping strategy, namely Emotional Focused Coping, where this strategy is used by people who are chronic and have low quality of life. There is a relationship between pain acceptance and quality of life (p = 0.006), it is found that high pain acceptance makes individuals adapt and reduce their attention to pain so as to optimize their daily functioning. Conclusion: There is no significant relationship between coping strategies and quality of life, but there is a significant relationship between pain acceptance and quality of life.