Mg-Al-NO3 hydrotalcite (p-LDH) was employed as a carrier for the controlled release of 5-Fluorouracil (5-FU). The p-LDH was pretreated by acid-pretreatment to gain a more stable material (a-LDH) in acid medium for oral administration. It demonstrated that the a-LDH had smaller crystal size, particle sizes and higher permanent charge density (σp) compared with that of the p-LDH by means of XRD, SEM, FT-IR, UV-vis DRS, TG-DSC, BET/BJH and other techniques. The FU/a-LDH and FU/p-LDH delivery systems were obtained using anion-exchange method. The in vitro 5-FU drug release studies showed that no burst release phenomenon was observed at the beginning of release tests. The in vitro 5-FU release behaviors of the delivery systems at initial pH 4.6 and 7.5 were studied which could be described by first-order and Bhaskas models. Combined with the XRD and FT-IR analyses of the solid residues of the FU/a-LDH and FU/p-LDH after the release, it was found that the dissolution mechanism was mainly responsible for the release behavior of the FU/p-LDH at initial 4.6, while the anion-exchange between intercalated 5-FU and phosphate anions mechanism was responsible for the FU/a-LDH at pH 4.6 and 7.5 as well as FU/p-LDH at pH 7.5. It is concluded that the hydrotalcites could be used as the basis of a tunable drug delivery carrier for 5-FU.

A new image encryption scheme is proposed with a combination of block scrambling, closed-loop diffusion, and DNA molecular mutation. The new chaotic block scrambling mechanism is put forward to replace the traditional swapping rule by combining the rectangular-ambulatory-plane cyclic shift with the bidirectional random disorganization. The closed-loop diffusion strategy is designed to form a feedback system, which improves the anti-interference capacity of the algorithm. To further destroy the blocks characteristics and eliminate the correlations among adjacent blocks, two efficient methods of DNA molecular mutation are adopted in the mutation stage. Moreover, the proposed algorithm possesses a large key space and the keys are highly related with the plaintext image. Experimental results demonstrate that the suggested image encryption strategy is practicable and has strong ability against a variety of common attacks.

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In this paper, inspired to the high-speed global search ability for genetic algorithm and the positive feedback mechanism for ant colony algorithm, our energy-efficient scheme, called ACGR, was proposed for routing optimization design, in which the communication messages, treated as ants with limited lifetime, are sent by nodes for searching the optimal routing path. Through the proposed scheme, multiple candidate routing paths could be obtained firstly. Then each candidate path is considered as a gene sequence and through the selection, crossover and mutation operations on them, the optimal energy routing path is determined. Simulation results have shown that the proposed algorithm provides promising solution because it takes into account the energy of each node, and extends the lifetime of the wireless sensor network.