Ischemic heart disease is the leading cause of death worldwide. Many patients with chronic myocardial ischemia are not suitable for surgery and have no effective drug treatment; they are called "no-option" patients. This study finds that umbilical cord-derived mesenchymal stromal cells transplanted by intracoronary delivery combined with two intravenous administrations was safe and could significantly improve left ventricular function, perfusion, and remodeling in a large-animal model of chronic myocardial ischemia, which provides a new choice for the no-option patients. In addition, this study used clinical-grade mesenchymal stem cells with delivery and assessment methods commonly used clinically to facilitate further clinical transformation.

Investigations on mixed-valent complexes in the Class II/ Class III frontier have been a particularly interesting issue due to their special electron delocalization. In this work, a pair of cyanidometal-/ isocyanidometal-bridged Ru−Ru−Ru compounds, cis-[Cp(dppe)Ru− B−Ru(dppe)Cp] 2+ (B = NCRu(bpy) 2 CN, 1 2+ ; B = CNRu(bpy) 2 NC, 2 2+ ; Cp = 1,3-cyclopentadienyl, dppe = 1,2-bis(diphenlyphosphine)ethane, bpy = 2,2′-bipyridine), and one-electron oxidized 1 3+ and 2 3+ were synthesized and well characterized. For the two-electron oxidized 1 4+ and 2 4+ , their Fourier transform infrared (FTIR) and UV−vis−NIR spectra were investigated by employing spectroelectrochemical methods. The time-dependent density-functional theory (TDDFT) calculations and the experimental results indicate that the one-/two-electron oxidized mixed-valent compounds belong to Class II−III systems.

Mixed-valence (MV) complexes containing non-innocent ligands are excellent models for the investigation of the electron-transfer process. A series of twelve bimetallic cyanide-bridged complexes [CpMen(dppe)RuCNFeLx][A](A = PF6- or I-, CpMen =...