No abstract

Discrete Fourier Transform is widely used in signal processing for spectral analysis, filtering, image enhancement , OFDM etc.. Cyclic convolution based approach is one of the techniques used for computing DFT. Using this approach an N point DFT can be computed using four pairs of [(M-1)/2]-point cyclic convolution where M is an odd number and N=4M. This work proposes an architecture for convolution based DFT and its FPGA implementation. Proposed architecture comprises of a pre-processing element, systolic array and a post processing stage. Processing element of systolic array uses a tag bit to decide on the type of operation (addition/subtraction) on the input signals. Proposed architecture is simulated for 28 point DFT using ModelSim 6.5 and synthesized using Xilinx ISE10.1 using Vertex 5 xc5vfx100t-3ff1738 FPGA as the target device and can operate at a maximum frequency of 224.9MHz. The performance analysis is carried out in terms of hardware utilization and computation time and compared with existing similar architectures. Further, as the convolution based DCT has two systolic arrays similar to that of DFT , a unified architecture is proposed for 1D DFT/1D DCT.

Background The advent of COVID pandemic disrupted routine antimicrobial stewardship(ASP) activities. We implemented a modified ASP audit in COVID locations using electronic stewardship forms inorder to monitor all antibiotics prescribed to COVID patients and assess them based on WHO AWaRe index. Methods Our prospective audit included all COVID inpatients who received antimicrobial prescriptions in 70 bedded covid area during the period from May 1st, 2021 to March 31st, 2022. All antimicrobial prescriptions were tracked using the daily review of the pharmacy consumption charts in Covid locations and prescriptions were categorised as per AWaRe index. For all reserve antimicrobial prescriptions link for REDCap based E – stewardship forms were sent to the physician in charge of the covid locations. Results Among 3484 COVID patients reviewed from May 1st 2021 to March 31st 2022, 2152 (61.7%) patients were prescribed with antimicrobials. The highest consumption of antimicrobials prescribed belonged to Watch group( 1937/2152, 90%) followed by Access (151/2152, 7.2%) and Reserve categories (64/2152, 3%) of WHO AWaRe index. Among the Watch group, the highest consumption was observed for Azithromycin (748/2152, 34.7%), followed by ceftriaxone(589/2152,27.3%) , piperacillin- tazobactam(400/2152,18.5%) and Meropenem(187/2152, 8.6%). Linezolid (22/2152, 1.0%) accounted for highest consumption among Reserve group, followed by Ceftazidime –Avibactam (17/2152, 0.7%) and colistin(14/2152, 0.6%). Conclusion The study successfully demonstrated the feasibility of implementing modified antimicrobial stewardship in Covid locations during the pandemic, especially in presence of unmet need for targeted strategies for driving antimicrobial stewardship Disclosures All Authors: No reported disclosures.

Rosai Dorfman disease is a rare histiocytic disorder. It is also known as Sinus Histiocytosis. It is with massive lymphadenopathy involves an overproduction of a type of white blood cell. The disease is rarely associated with intracranial and intraorbital involvement. Intracranial Rosai-Dorfman can mimic meningioma. Other pathologies also underline its pathologies. Here, we report a nine-year-old boy with a history of proptosis of the right eye and presenting with multiple skull lesions. Histopathological study revealed Sphenopetroclival lesion, which features that of Rosai Dorfman Disease. His MRI scan of the brain was taken, which showed evidence of right optic nerve meningioma with sella and suprasellar extension, causing severe proptosis. The child underwent right frontotemporal craniotomy with petrosectomy and Transylvanian, subtemporal approach to multicompartmental Rosai-Dorfmans lesion. After four months, the patient had a recurrence of the disease on which chemotherapy and steroids were started, which also did not show much response while taking an MRI scan. A corticosteroid is a useful option in the Central Nervous System Rosai Dorfman disease treatment. But this patient showed a negative outcome to the treatment.