Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GDF15 binds specifically to GDNF family receptor α-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF15 stimulation. We also found that GDF15-mediated reductions in food intake and body weight of mice with obesity were abolished in GFRAL-knockout mice. We further found that GFRAL expression was limited to hindbrain neurons and not present in peripheral tissues, which suggests that GDF15-GFRAL-mediated regulation of food intake is by a central mechanism. Lastly, given that GDF15 did not increase energy expenditure in treated mice with obesity, the anti-obesity actions of the cytokine are likely driven primarily by a reduction in food intake.

Institutional theory has become an increasingly common lens in entrepreneurship research. Over the past years, the number of entrepreneurship studies that adopt institutional perspective (EIn research) has grown dramatically. This review systematically examines extant EIn research, analyzing 194 articles published in 11 leading journals from 1992 to 2014. In this review, we focus on three characteristics of the articles: institutional logic, level of analysis, and methodology. Further, we identify three distinct periods of EIn research: the conceptual phase, 1992–2000, the exploration phase 2001–2007, and the acceptance phase 2008–2014. This allows us to provide detailed discussion on main characteristics of the articles and identify evolutionary trends of this research area. The overall surge of articles with institutional perspective in entrepreneurship research is promising. We can see an increasing variation of methods being applied and a growing mutual interest between entrepreneurship and institutional theory researchers. Yet, we find substantial biases and omissions in the application of institutional theory. There is a focus on national level analysis with assuming state and market logics. For EIn to move forward it has to move closer to field/industry level analysis and add new insights into entrepreneurship and alternative logics. Based on our framework and additional insights gained from the review, we outline directions for future EIn research.

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Purpose This paper aims to evaluate the progress made in understanding the impact of multi-level institutions on entrepreneurship. Design/methodology/approach Based on scientific articles published between 1992 and 2017, the authors take a unique focus on both institutional theory applied and research topics of this area. Bibliometric method and systematic literature review method are used. Findings The results demonstrate that although institutional theory is well prepared for entrepreneurship context operating at different levels, the major knowledge foundation used predominantly focuses on macro and meso level. When it comes to research topics, entrepreneurship is often simplified as the founding of new venture, and the unique venture founding process has rarely been explored. Originality/value This paper is the first to provide a full picture of the multi-level institutions and their consequences on different kinds of entrepreneurial activities. The authors’evaluation of this research area also points out directions for future study.