The methane uptakes of six double halogen substituted covalent organic frameworks (COFs) based on COF-102 were simulated with grand canonical Monte Carlo simulation at 298 K and pressure ranges from 1 to 80 bar. The simulation shows that COF-102-1,4-2I reaches the DOE target of 180 V(STP)/V for methane delivery. The current study highlights the correlation between the structure and the adsorption property of the double halogen substituted COF-102. In COF-102-1,4-2I, the triangle arrangement of the six I atoms around the central B3O3 ring brings close contact between I atom and B3O3 ring, and thus enhances the attraction of CH4 with high CH4 density in the vicinity above and below this region, especially in particular adsorption sites. Such favorable structural arrangement, altogether with the strongest I–CH4 attraction among the halogen substituent in this study, gives the highest isosteric heat as well as the CH4 uptakes at 298 K and 35 bar in the hypobaric region. The result in this study demonstrates that double halogen substituted COF-102 is capable of increasing CH4 uptakes for practical applications.

Aging poses a major risk factor for cardiovascular diseases, the leading cause of death in the aged population. However, the cell type-specific changes underlying cardiac aging are far from being clear. Here, we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with age. We found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional profiles. Via transcription regulatory network analysis, we identified FOXP1, a core transcription factor in organ development, as a key downregulated factor in aged cardiomyocytes, concomitant with the dysregulation of FOXP1 target genes associated with heart function and cardiac diseases. Consistently, the deficiency of FOXP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes. Altogether, our findings depict the cellular and molecular landscape of ventricular aging at the single-cell resolution, and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases.

Imitation of human behaviors is one of the effective ways to develop artificial intelligence. Human dancers, standing in front of a mirror, always achieve autonomous aesthetics evaluation on their own dance motions, which are observed from the mirror. Meanwhile, in the visual aesthetics cognition of human brains, space and shape are two important visual elements perceived from motions. Inspired by the above facts, this paper proposes a novel mechanism of automatic aesthetics evaluation of robotic dance motions based on multiple visual feature integration. In the mechanism, a video of robotic dance motion is firstly converted into several kinds of motion history images, and then a spatial feature (ripple space coding) and shape features (Zernike moment and curvature-based Fourier descriptors) are extracted from the optimized motion history images. Based on feature integration, a homogeneous ensemble classifier, which uses three different random forests, is deployed to build a machine aesthetics model, aiming to make the machine possess human aesthetic ability. The feasibility of the proposed mechanism has been verified by simulation experiments, and the experimental results show that our ensemble classifier can achieve a high correct ratio of aesthetics evaluation of 75%. The performance of our mechanism is superior to those of the existing approaches.

Partial discharge live detection of GIS can effectively find internal defects, but it is often interfered by surrounding environmental noise, which affects the correct identification and judgment of defect signals. This paper introduces the application of AE and UHF technique in the live detection of GIS, which successfully recognizes the external interference signal, analyzes the cause of abnormal partial discharge signal based on signal characteristics, and uses the method by calculating time difference to locate the source of the signal. An internal checking on the equipment were conducted based on the test results while the equipment were stopped, and verified the existence of floating fault inside GIS.