Umpolung is a powerful strategy in organic chemistry to construct complex molecules. Herein we report a novel, rapid and efficient route to spiroquinazolinone framework via an umpolung strategy mediated by...

Herein, we reported a metal-free photoredox/phosphine-catalyzed C–H amination of arenes. This allows for concise synthesis of highly functionalized N-arylphthalimides from readily available N-hydroxyphthalimides directly, without the preparation of activated N-hydroxyphthalimide intermediates. Mechanistic studies reveal that the radical is produced via phosphine-mediated N–O bond scission.

The cleavage of the inert C(sp2)−OMe bond via photocatalysis is an attractive alternative to the well-established Ni-catalyzed methods, and is also a challenge in organic chemistry. Herein we report a...