The first example of metal-free B(CF)-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81-95% yield with 80-99% de. This protocol was further applied in the total synthesis of cinacalcet.

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Umpolung is a powerful strategy in organic chemistry to construct complex molecules. Herein we report a novel, rapid and efficient route to spiroquinazolinone framework via an umpolung strategy mediated by...

An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas is described. The protocol proceeds via domino double [4+2] annulations and features eco-benign catalyst & solvent,...