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Cotton is an important economic crop, and many loci for important traits have been identified, but it remains challenging and time-consuming to identify candidate or causal genes/variants and clarify their roles in phenotype formation and regulation. Here, we first collected and integrated the multi-omics datasets including 25 genomes, transcriptomes in 76 tissue samples, epigenome data of five species and metabolome data of 768 metabolites from four tissues, and genetic variation, trait and transcriptome datasets from 4180 cotton accessions. Then, a cotton multi-omics database (CottonMD, http://yanglab.hzau.edu.cn/CottonMD/) was constructed. In CottonMD, multiple statistical methods were applied to identify the associations between variations and phenotypes, and many easy-to-use analysis tools were provided to help researchers quickly acquire the related omics information and perform multi-omics data analysis. Two case studies demonstrated the power of CottonMD for identifying and analyzing the candidate genes, as well as the great potential of integrating multi-omics data for cotton genetic breeding and functional genomics research.

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Moving object detection is a fundamental step in video surveillance system. To eliminate the influence of illumination change and shadow associated with the moving objects, we proposed a local intensity ratio model (LIRM) which is robust to illumination change. Based on the analysis of the illumination and shadow model, we discussed the distribution of local intensity ratio. And the moving objects are segmented without shadow using normalized local intensity ratio via Gaussian mixture model (GMM). Then erosion is used to get the moving objects contours and erase the scatter shadow patches and noises. After that, we get the enhanced moving objects contours by a new contour enhancement method, in which foreground ratio and spatial relation are considered. At last, a new method is used to fill foreground with holes. Experimental results demonstrate that the proposed approach can get moving objects without cast shadow and shows excellent performance under various illumination change conditions.