An ionic crosslinking nanocellulose/sodium alginate (BC/SA) hybrid hydrogel was prepared as a dual-stimuli responsive release system. The drug release rate of BC/SA hybrid hydrogels in vitro not only depend on pH value but also depend on the presence of electric stimulus.

With the rapid development of the wearable detector and medical devices, flexible biosensing materials have received more and more attention. In this work, a novel flexible and conductive biocompatible composite with electronic and ionic bioconductive ability was demonstrated to fabricate a new flexible bioelectrode used for electrophysiological signal detection. This composite was prepared by the in situ self-polymerization of dopamine on the nanofiber of bacterial cellulose (BC) under the neutral pH condition. By using this method, poly(dopamine) (PDA) could form a uniform and continuous wrapped layer on the BC nanofiber that can prevent the aggregation of PDA caused by rapid polymerization under the conventional alkaline condition. In addition, a fabricated film with a special structure is suitable for the transportation of electrons and ions existing in it. Moreover, the flexible conductive film (FCF) reveals an extremely tensile strength, which is 2 times higher than the pure BC in addition to a high electric conductivity, which reaches a value of 10 S/cm with a high PDA content. Furthermore, the result of electrocardiogram signal testing shows that the antibacterial property of the FCF bioelectrode has an excellent stability, which is comparable to or better than the commercially available electrode. The BC/PDA-FCF provides a platform for the creation of flexible conductive biomaterials for wearable response devices.

A novel biodegradable PHBV-based polyurethane was designed and synthesized by using PHBV, MDI and PEG.

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