BackgroundAlzheimer's disease (AD) is a common, progressive, irreversible, and fatal neurodegenerative disorder with rapidly increasing worldwide incidence. Although much research on magnetic resonance imaging (MRI) of the white matter (WM) in AD has been published, no bibliometric analysis study has investigated this issue. Thus, this study aimed to provide an overview of the current status, hotspots, and trends in MRI of WM in AD.MethodsWe searched for records related to MRI studies of WM in AD from 1990 to 2022 in the Web of Science Core Collection (WOSCC) database. CiteSpace (version 5.1.R8) and VOSviewer (version 1.6.19) software were used for bibliometric analyses.ResultsA total of 2,199 articles were obtained from this study. From 1990 to 2022, the number of published articles showed exponential growth of y = 4.1374e0.1294x, with an average of 17.9 articles per year. The top country and institutions were the United States and the University of California Davis, accounting for 44.52 and 5.32% of the total studies, respectively. The most productive journal was Neurology, and the most co-cited journal was Lancet Neurology. Decarli C was the most productive author. The current research frontier trend focuses on the association between small vessel disease and AD, the clinical application and exploration of diffusion MRI, and related markers.ConclusionThis study provides an in-depth overview of publications on MRI of WM in AD, identifying the current research status, hotspots, and frontier trends in the field.

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preschool children is significantly increased in the last decade (student t-test, p). Conclusions Data from 2013 indicate that about 30% of young children encounter the obesity problem. Therefore, children at this age already should represent the priority population for intervention strategies such as control of diet and/or physical activity. Background and aims Osteogenesis imperfecta (OI) is a disorder that leads to fragile bones and significant morbidity. The aim was to find out the prevalence of Vitamin D deficiency in children with OI. Methods In present study, 15 children with clinically severe OI on zoledronate therapy were studied. The biochemical parameters tested were Vit D level and urine DPD level along with the routine parameters like Ca, Po, ALP, and urinary calcium creatinine ratio. We used a cut-off value of 30 ng/ml for vitamin D deficiency. Also cost effectiveness of zolendronate therapy was assessed. Results Most of the OI patients were vit D deficient (80%). The mean value of vitamin D in the study was 21.89 ± 9.76 (mean ±SD), and median value was 25.49 units. This treatment in present study did not significantly increase the financial burden on the family using alternate brand of zolendronate. Conclusions High prevalence od Vitamin D deficiency in OI may be due to their less mobility and thus less sun exposure, the low vit D level can decrease their response to zolendronate treatment Vitamin D supplementation may be needed at higher doses along with oral calcium in patients with OI put on bisphosphonates therapy. Generic preparations of zoledronate do not increase the burden of therapy in patients with OI. Further studies are needed to find out long term side effects of zoledronate therapy in children. -2014-307384.748 Background In this study we aimed to investigate the relationship between maternal and neonatal 25(OH)D levels. Methods The subjects were 58 mothers and their newborns who were born between February 2012 and April 2012. Blood specimens were obtained within 72 h of birth and from mothers. Serum 25(OH)D concentrations were measured. Vitamin D deficiency was defined as serum concentrations ≤20 ng/mL. Results The mean gestational age and birth weight of preterm infants were 33.06 ± 2.2 weeks and 2125.4 ± 546 g and for term infants were 38.84 ± 1 weeks and 3470.3 ± 451 g, respectively. Sociodemographic characteristics of mothers were not significantly different between groups. PO-0077 PO-0078

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