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Carboxymethyl dextran (CMD) with varying degrees of substitution was prepared and used as biocompatible coating for magnetic iron oxide nanoparticles. An oligonucleotide (19-mer) was coupled to the CMD-coated particles as a model compound for DNA fragments. Transmission electron microscopy investigations on the cellular uptake of the particles by different tumor cell lines demonstrated that both the CMD-coated and the oligonucleotide-coupled particles are internalized by the cells and deposited in cellular endosomes. The nanoparticles prepared have potential applications in tumor diagnosis and therapy.

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