Ferrofluids of magnetic multicore nanoparticles for biomedical applications

Dutz, Silvio; Clement, Joachim H.; Eberbeck, Dietmar; Gelbrich, Thorsten; Hergt, R.; Müller, Robert N.; Wotschadlo, Jana; Zeisberger, Matthias

doi:10.1016/j.jmmm.2009.02.073

Cited by 144 publications

(111 citation statements)

References 22 publications

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“…All prepared nanoparticle suspensions show a stability against sedimentation of several months as described in previous investigations [17,18].…”

Section: Preparation Of Mnpsupporting

confidence: 72%

Preparation of Core-Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles

Weidner¹,

Gräfe²,

Lühe³

et al. 2016

Nano Online

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Nanoparticles experience increasing interest for a variety of medical and pharmaceutical applications. When exposing nanomaterials, e.g., magnetic iron oxide nanoparticles (MNP), to human blood, a protein corona consisting of various components is formed immediately. The composition of the corona as well as its amount bound to the particle surface is dependent on different factors, e.g., particle size and surface charge. The actual composition of the formed protein corona might be of major importance for cellular uptake of magnetic nanoparticles. The aim of the present study was to analyze the formation of the protein corona during in vitro serum incubation in dependency of incubation time and temperature. For this, MNP with different shells were incubated in fetal calf serum (FCS, serving as protein source) within a water bath for a defined time and at a defined temperature. Before and after incubation the particles were characterized by a variety of methods. It was found that immediately (seconds) after contact of MNP and FCS, a protein corona is formed on the surface of MNP. This formation led to an increase of particle size and a slight agglomeration of the particles, which was relatively constant during the first minutes of incubation. A longer incubation (from hours to days) resulted in a stronger agglomeration of the FCS incubated MNP. Quantitative analysis (gel electrophoresis) of serum-incubated particles revealed a relatively constant amount of bound proteins during the first minutes of serum incubation. After a longer incubation (>20 min), a considerably higher amount of surface proteins was determined for incubation temperatures below 40°C. For incubation temperatures above 50°C, the influence of time was less significant which might be attributed to denaturation of proteins during incubation. Overall, analysis of the molecular weight distribution of proteins found in the corona revealed a clear influence of incubation time and temperature on corona composition.

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“…All prepared nanoparticle suspensions show a stability against sedimentation of several months as described in previous investigations [17,18].…”

Section: Preparation Of Mnpsupporting

confidence: 72%

Preparation of Core-Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles

Weidner¹,

Gräfe²,

Lühe³

et al. 2016

Nano Online

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“…Adding a solvent in which the polymer was insoluble yielded small secondary structures, while adding a solvent in which the polymer is soluble allowed for larger structures embedding a large number of primary nanocrystals to be formed. Different types of molecules, as encapsulating agents of iron oxide nanoparticles, have been used, including polymers/block copolymers ( Figure 6A, B) [24,99,98,101,94], micelles ( Figure 6C) [100], polysaccharides [22,32], or hydrogels [95]. For example, aggregated iron oxide particles with controlled size have been prepared by utilizing methods based on acid/base interactions involving pre-formed nanocrystals in an organic solvent ( Figure 6C) [100].…”

Section: Encapsulation Of Pre-formed Nanocrystalsmentioning

confidence: 99%

“…Colloidal nanoclusters have been found to be ferromagnetic/ferrimagnetic [21,32,36,80,81,83,89,98] or superparamagnetic [13-16, 22, 24, 31, 33, 35, 77, 79, 82, 84, 85] at ambient conditions. The ferrimagnatic/ferromagnetic behavior of nanoclusters may be attributed either to ferromagnetic incorporated nanoparticles of sufficient large diameter ( > 20 nm) [80,81] or to strong intra-cluster interactions [21].…”

Section: In the Quest For Exchange Coupling Among Surface Spinsmentioning

confidence: 99%

“…Different morphologies, compact or loose structures with diameters ranging from 30 to a few hundred nm have been obtained with the previous synthesis strategies. Colloidal assemblies of inorganic nanocrystals are commonly called nanoclusters [15,[21][22][23][24][25][26][27][28][29], but in the literature, they can also be found as nanoflowers [30], nanoroses [17], multi-core particles [31,32], nanoassemblies [13,14,33,34], porous particles [35], flower-like mesocrystals [36], nanobeads [37,38], and pomegranate-like particles [34]. Furthermore, it is worth noting that these can be delivered with diverse chemical origin, including nanoclusters of ZnO [39,40], Co 3 O 4 [41], CuO [42], In 2 O 3 [40], CoO [40], MnO [40], ZnSe [40], CuCr 2 S 4 [43], PbS [44], and TiO 2 [45].…”

Section: Introductionmentioning

confidence: 99%

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Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Κωστοπούλου

Lappas

2015

Nanotechnology Reviews

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Magnetic particles of optimized nanoscale dimensions can be utilized as building blocks to generate colloidal nanocrystal assemblies with controlled size, well-defined morphology, and tailored properties. Recent advances in the state-of-the-art surfactant-assisted approaches for the directed aggregation of inorganic nanocrystals into cluster-like entities are discussed, and the synthesis parameters that determine their geometrical arrangement are highlighted. This review pays attention to the enhanced physical properties of iron oxide nanoclusters, while it also points to their emerging collective magnetic response. The current progress in experiment and theory for evaluating the strength and the role of intra-and inter-cluster interactions is analyzed in view of the spatial arrangement of the component nanocrystals. Numerous approaches have been proposed for the critical role of dipole-dipole and exchange interactions in establishing the nature of the nanoclusters' cooperative magnetic behavior (be it ferromagnetic or spin-glass like). Finally, we point out why the purposeful engineering of the nanoclusters' magnetic characteristics, including their surface functionality, may facilitate their use in diverse technological sectors ranging from nanomedicine and photonics to catalysis.

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“…The SAR of ferromagnetic MNPs can be determined from minor magnetization loops. [4][5][6] This method cannot be, however, applied to superparamagnetic nanoparticles, which do not show hysteresis loops, but SAR can be obtained from the measurement of the out-of-phase ac magnetic susceptibility, Љ, by using the theoretical expressions that relate both magnitudes. 7 One drawback of the latter method is that, due the characteristics of the currently used setups, Љ is often measured with acfield parameters different than those used for MFH.…”

mentioning

confidence: 99%

Adiabatic magnetothermia makes possible the study of the temperature dependence of the heat dissipated by magnetic nanoparticles under alternating magnetic fields

Natividad

Castro

Mediano

2011

Applied Physics Letters

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Mapping of hyperthermic tumor cell death in a microchannel under unidirectional heating Biomicrofluidics 6, 014120 (2012) The use of magnetic nanoparticles in thermal therapy monitoring and screening: Localization and imaging (invited) J. Appl. Phys. 111, 07B317 (2012) Analysis of heating effects (magnetic hyperthermia) in FeCrSiBCuNb amorphous and nanocrystalline wires J. Appl. Phys. 111, 07A314 (2012) Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia J. Appl. Phys. 111, 07B306 (2012) Influence of a transverse static magnetic field on the magnetic hyperthermia properties and high-frequency hysteresis loops of ferromagnetic FeCo nanoparticles

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Ferrofluids of magnetic multicore nanoparticles for biomedical applications

Cited by 144 publications

References 22 publications

Preparation of Core-Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles

Preparation of Core-Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Adiabatic magnetothermia makes possible the study of the temperature dependence of the heat dissipated by magnetic nanoparticles under alternating magnetic fields

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