BackgroundMothers of preterm infants often have symptoms of anxiety and depression, recognized as risk factors for the development of cardiovascular diseases and associated with low rates of heart rate variability (HRV). This study aimed to evaluate the influence of music therapy intervention on the autonomic control of heart rate, anxiety, and depression in mothers.MethodsProspective randomized clinical trial including 21 mothers of preterms admitted to the Neonatal Intensive Care Unit of a tertiary hospital, recruited from August 2015 to September 2017, and divided into control group (CG; n = 11) and music therapy group (MTG; n = 10). Participants underwent anxiety and depression evaluation, as well as measurements of the intervals between consecutive heartbeats or RR intervals for the analysis of HRV at the first and the last weeks of hospitalization of their preterms. Music therapy sessions lasting 30–45 min were individually delivered weekly using receptive techniques. The mean and standard deviation of variables were obtained and the normality of data was analyzed using the Kolmogorov-Smirnov test. The paired sample t-test or Wilcoxon test were employed to calculate the differences between variables before and after music therapy intervention. The correlations anxiety versus heart variables and depression versus heart variables were established using Spearman correlation test. Fisher’s exact test was used to verify the differences between categorical variables. A significance level of p < 0.05 was established. Statistical analysis were performed using the Statistical Package for the Social Sciences, version 20.ResultsParticipants in MTG had an average of seven sessions of music therapy, and showed improvement in anxiety and depression scores and autonomic indexes of the time domain (p < 0.05). Significant correlations were found between depression and parasympathetic modulation using linear (r = − 0.687; p = 0.028) and nonlinear analyses (r = − 0.689; p = 0.027) in MTG.ConclusionMusic therapy had a significant and positive impact on anxiety and depression, acting on prevention of cardiovascular diseases, major threats to modern society.Trial registrationBrazilian Registry of Clinical Trials (no. RBR-3x7gz8). Retrospectively registered on November 17, 2017.
Acmella oleracea (L.) R. K. Jansen, popularly known as jambu in Northern Brazil, is widely used in folk medicine and local cuisine. Its consumption in different ways reinforces the need for safety assessments. In this study, the major compounds found in the hydroethanolic extract of A. oleracea flowers (EHFAO) were characterized by ultra-performance liquid mass spectrometry (UHPLC-ESI-QTOF-MS/MS). The effects of oral administration of 100/mg/kg of EHFAO extract over 60 days in male spontaneously hypertensive (SHR) and Wistar (WR) rats and the in silico ADME/Tox predictions, lipophilicity, and water solubility were accomplished for the compounds identified. Spilanthol was detected as the foremost major compound at a concentration of 97.7%, followed by 1.53% scopoletin and 0.77% d-limonene. The treatment with EHFAO did not alter the animals´ weight over the studied period. Moderate alterations were observed solely in the hepatic enzymes AST (WR = 97 UI/L and SHR = 150 UI/L ∗ p < 0.05 ) and ALT (WR = 55 UI/L and SHR = 95 UI/L ∗ p < 0.05 ), while no relevant histopathological alterations were found. The in-silico study confirmed the in vivo findings, as the identified compounds were considered highly bioactive orally, due to their drug similarity profiles, adequate lipid solubility, bioavailability, and pharmacokinetics. Therefore, the chronic treatment with EHFAO was found safe at the concentration of 100/mg/kg, with no interference in the blood pressure levels neither appreciable toxic effects.
Background: Acute Kidney Injury (AKI), a common disease of the urinary system, can be induced by high doses of gentamicin (GM). The Renin-Angiotensin System exerts a key role in the progression of the AKI since elevated intrarenal levels of Ang II, and ACE activity is found in this condition. However, it is unknown whether oral administration of Ang-(1-7), a heptapeptide that evokes opposite effects of Ang II, may attenuate the renal injuries induced by gentamicin. Objectives: To evaluate the effects of Ang (1-7) on GM-induced renal dysfunction in rats. Methods: AKI was induced by subcutaneous administration of GM (80 mg/Kg) for 5 days. Simultaneously, Ang-(1-7) included in hydroxypropyl β-cyclodextrin (HPβCD) was administered by gavage [46 μg/kg HPβCD + 30 μg/kg Ang- (1-7)]. At the end of the treatment period (sixth day), the rats were housed in metabolic cages for renal function evaluation. Thereafter, blood and kidney samples were collected. Results: The Ang-(1-7) attenuated the increase of the plasmatic creatinine and proteinuria caused by GM but did not change the glomerular filtration rate nor tubular necrosis. Ang-(1-7) attenuated the increased urinary flow and the fractional excretion of H2O and potassium observed in GM rats but intensified the elevated excretion of sodium in these animals. Morphological analysis showed that Ang-(1-7) also reduced the tubular vacuolization in kidneys from GM rats. Conclusion: Ang-(1-7) promotes selective beneficial effects in renal injuries induced by GM.
O estudo da Anatomia busca compreender os componentes motores e funcionais a partir de diversas expressões do movimento humano.O presente trabalho buscou realizar apresentações artísticas e esportivas, além de identificar os principais movimentos anatômicos envolvidos. O trabalho foi aprovado pelo Comitê de Ética em Pesquisa (n° 1.007.285) e desenvolvido por acadêmicos de Educação Física Licenciatura,em escolas/creches/centros de treinamento/parques em Goiânia-GO entre os dias 10/06/2016 a 20/07/2017. Foram realizadas apresentações artísticas: Ballet/Pole Dance/Zumba e esportivas: Futevôlei/UltimateFrisbee/Judô/BodyWeight Training/Kravmagá. Em todos os exercícios, os maiores grupos musculares trabalhados foram os membros inferiores e superiores. Em menor frequência, foi observado a ativação da musculatura do abdome. Pode-se concluir que o ensino dos componentes motores aplicados às práticas esportivas e artísticas promoveu a construção do conhecimento para além da sala de aula contribuindo para a formação acadêmica dos estudantes e promoveu uma aproximação entre a comunidade e a Universidade.
A Universidade Federal de Goiás realiza anualmente o Espaço das Profissões, evento que promove integração da comunidade acadêmica e a comunidade externa. A sala interativa do curso de biomedicina é um espaço para expor diferentes áreas de atuação do biomédico demonstrando fatos sobre a graduação e a profissão. O objetivo da ação foi levar a comunidade externa o conhecimento adquirido na graduação, promover interação entre os discentes do curso e o público e permitir que ambos tenham contato com as habilitações do biomédico. Mais 20 habilitações foram representadas por atividades interativas e experimentais. Houve uma resposta positiva do público, que se mostrou bastante interessado e entusiasmado com as apresentações temáticas. Os discentes de Biomedicina se mostraram proativos, motivados e comprometidos com sua futura profissão. Foi possível observar a importância de ações de extensão que permitem aproximação da universidade a comunidade externa e despertar o interesse dos visitantes.Palavras-chave: Espaço das profissões, biomedicina, interação social, Extensão.
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