Immune checkpoint inhibitors have shown anti-tumour activity in cancers such as melanoma, renal cell carcinoma, non-small-cell lung cancer, urothelial carcinoma, colorectal cancer, and Hodgkin’s lymphoma. Though immune checkpoint inhibitors have revolutionized the treatment and prognosis of some advanced malignancies, they are also associated with a significant risk of immune-related adverse events. These adverse events can occur in any organ system, but gastrointestinal side effects are among the most commonly reported, with manifestations ranging from mild diarrhoea to severe colitis, sharing some features with inflammatory bowel disease. Anticipating a greater use of these drugs in the future, gastroenterologists should expect to be increasingly faced with gastrointestinal immune-related adverse events. Knowledge of these toxicities, as well as effective management algorithms, is essential to enable early diagnosis and treatment, decreasing morbidity and mortality. We reviewed the currently available literature on gastrointestinal toxicity induced by immune checkpoint inhibitors, namely the clinical features, diagnosis, and management.

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Dislocation of the distal radioulnar joint (DRUJ) usually occurs associated with a distal radius fracture. An isolated dislocation, without a radius fracture, is a rare situation.We present a case of neglected isolated DRUJ dislocation in a 30-year-old manual laborer. The treatment was performed 4 months after the initial injury. Open reduction and fixation were performed. This resulted in a stable, pain-free joint, and the patient resumed his previous work.Surgical techniques of foveal reattachment and dorsal capsuloplasty have been described for chronic DRUJ instability. An isolated and dislocated DRUJ is an uncommon injury that may be misdiagnosed and initially mistreated. There haven't been many reports in the literature of a case such as this.