Background: The goal of this systematic review and meta-analysis is to determine the effect of diet on telomere length. Methods: We searched the following databases: MEDLINE, Embase, LILACS, CINAHL, ISI Web of Science, and Scopus, as well as the Cochrane Central Register of Controlled Trials and the National Institutes of Health, from inception to December 2016. Articles that assessed effects of diet on telomere length were included. Results: A total of 2,128 studies were identified, 30 were read in full, and 7 were systematically reviewed. Five RCTs were included in the meta-analysis, covering 9 diets; a total of 533 participants were included. Study heterogeneity (I2) was 89%, and differences were not identified regarding average telomere lengths (mean difference 1.06; 95% CI –1.53 to 3.65). Conclusion: The available evidence suggests that there is no effect of diet on telomere length, but the strong heterogeneity in the type and duration of dietary interventions does not allow any final statement on the absence of an effect of diet on telomere length.
Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. RESUMOObjetivos: Abordar, por meio de uma revisão da literatura, o manejo das queimaduras de mão, com ênfase nos cuidados iniciais. Métodos: No período entre fevereiro e julho de 2015, foram revisados 30 artigos selecionados nas bases de dados MedLine/PubMed, LILACS, SciELO e Google Acadêmico, inclusos tanto os de língua inglesa quanto portuguesa, publicados nos últimos 10 anos e que correspondessem aos seguintes descritores: queimadura de mão; ferimento de mão; tratamento agudo; tratamento primário; e seus correspondentes em inglês. Resultados: É apresentada a classificação das queimaduras conforme a profundidade, extensão e fatores agravantes. São abordadas as condutas iniciais que evitam complicações como mão em garra, síndrome compartimental e infecções. Os procedimentos iniciais incluem curativos oclusivos, escarotomia, fasciotomia, abertura do túnel do carpo, seguidos por curativos com agentes antimicrobianos tópicos, desbridamento e enxertos. São discutidos aspectos controversos sobre o momento mais indicado para a intervenção cirúrgica, caso esta seja necessária. Conclusões: A correta abordagem inicial da queimadura de mão poderá evitar sequelas irreversíveis. O manejo adequado na queimadura de mão inclui desde a avaliação clinica inicial da área queimada por um médico generalista à realização de condutas precoces com o objetivo de evitar a perda de função do membro e futuras reconstruções desnecessárias. A elevada incidência desse tipo de queimadura também acentua a relevância de uma conduta adequada. DESCRITORES: mãos; ferimentos e lesões; queimaduras; tratamento primário. ABSTRACT Aims:To address, through a literature review, the management of hand burns, with emphasis on the initial care. Methods: Between February and July 2015, 30 articles selected in the databases Medline/PubMed, LILACS, SciELO and Google Scholar were reviewed. Both the English and Portuguese languages were included in the search. Selected articles were published in the last 10 years and matched the following descriptors: hand burn; hand injury; acute treatment; primary treatment; and their counterparts in Portuguese. Results: Classification of burns is displayed, including depth, extent and aggravating factors. The initial management that avoid complications such as claw hand, compartment syndrome and infection is addressed. Early procedures include occlusive dressings, escharotomy, fasciotomy, and carpal tunnel opening, followed by dressings with topical antimicrobial agents, debridement and grafting. Controversial aspects are discussed on the most appropriate time for surgical intervention, if it is necessary. Conclusions: The correct early approach to hand burns can prevent irreversible consequences. The appropriate management on hand burns includes since the initial clinical evaluation of the burned ...
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