This study has shown that propolis is a promising bioactive component in dental products, especially for use in Cariology and Periodontology. Although there has been significant progress in applications of propolis, the field of dental products is still a growing area and it is important to encourage innovation and development of new products incorporating propolis based on knowledge of its composition and therapeutic properties.

Amphotericin B is most widely used antifungal drug of choice. We report a case of a 56-year-old man developed pain and skin swelling over right forearm at the intravenous access site during amphotericin B administration treatment given for mucormycosis, the post-operative of sinuses. After 4 hours of affected period, amphotericin B was administration. A well revealed thrombophlebitis of the right forearm was noted. The systemic reaction was assessed based on the naranjo algorithm and was found to be probable. The safety profile of amphotericin B and its adverse effects must be monitored on long term treatment usage.

Gastroesophageal Reflux Disease (GRD) is the most common form of esophagitis, where proton pump inhibitors are the most widely used drugs. This study aimed to perform a literature review about the clinical use and adverse reactions of proton pump inhibitors (PPIs). Treatment of GRD evolved in the 1970s, when the first PPI, timoprazole, was discovered and in 1979, omeprazole originated, with a high action on the proton bomb. The most potent drugs in gastric suppression are proton pump inhibitors where they act irreversibly in the proton pump H + , K + ,-ATPase, the suppression of acid secretion lasts for 24-48 hr. PPIs with prolonged use are associated with changes in the intestinal microbiota, which can be compared to changes seen with antimicrobials, in addition to altering the absorption of iron and Vitamin B 12 and the metabolism of calcium and magnesium. The population most susceptible to the appearance of the side effects of PPIs is the elderly, age is a factor that predisposes to the appearance of various pathologies and it is necessary to use many medications thus constituting a polypharmacy, in addition, may increase the risks of drug toxicity due to the hepatic metabolism of the elderly being compromised, this is a worrying condition, as it can cause, in addition to the side effects of PPIs, drug interactions, making pharmacotherapeutic follow-up essential, thus being able to make dose adjustments and assess possible drug-related problems and adverse drug reactions.

Bisphosphonate (BF) is a drug used to treat some bone pathologies, such as osteoporosis, multiple myeloma, Paget's disease, and to treat bone metastasis. These drugs increase the risk of osteonecrosis, where several factors are considered to be risk factors for this, including surgery for placing dental implants and tooth extraction. The objective of this present study was to conduct a literature review on the emergence of osteonecrosis in patients who are or have used BFand have undergone dental implant surgery. A literature review was carried out using the PUBMED, LILACS, Bireme and Scielo databases. To carry out this research, 24 articles were selected between the years 2008 and 2020, which were related to the topic of the use of BF in dental implantology. There is no clear relationship between BF and osseointegration of dental implants. Studies show that BFs increase the mechanical stability of implants if used locally, but they can also increase the risk of osteonecrosis of the jaw if used systemically. BFs have different effects at bone repair sites and bone remodeling sites. It is known that bone can be formed at the site of repair, but this drug will decrease bone formation to a similar level of bone resorption at the site of remodeling. Despite the risk, implant surgery is not contraindicated in patients undergoing oral treatment. The rate of osteonecrosis related to the use of BF is low, even so the professional must consider the risk and be cautious to prevent this from happening.

Background: Mucosal cyst of the maxillary sinus or antral pseudocyst is one of great importance injury, being the pathology that affects more the maxillary sinus. Their discovery, in most cases, it is for the interpretation of the images in routine panoramic radiography. Aims:The research aimed to evaluate the prevalence of mucous cyst in maxillary sinus in radiology clinic at Ceara Federal University. Material and Methods:To this study conduction, were analyzed 1996 panoramic radiographs from a digital file obtained between April 2011 to April 2013.Results: Aspects as gender, affected side and teeth absence next to the cyst in the respective quadrant were evaluated.It was observed in the sample the occurrence of 45 patients with suggested images of mucous cysts in maxillary sinus,making a prevalence of 2.25%. From them, 26 (57.8%) were female and 19 (42.2%) were male. 48 maxillary sinuswere affected with the wound, from which28 (58.3%) it was in the left side and 20 (41.7%) in the right site. Three patients presented the wound in both sides, what represents 6.7% of the affected patients. From those 48 Mucous retention cyst, 40 (83.3%) were not related to an edentulous area in ipsilateral quadrant and 8 (16.7%) were shown next to an edentulous area.