IntroducciónL os plasmocitomas constituyen neoplasias malignas de las células plasmáticas clonales. Pueden clasificarse en 3 diferentes subgrupos: mieloma múltiple (forma diseminada que interesa a la médula ósea) y 2 formas localizadas (plasmocitoma soliario intra y extramedular). La variante extramedular constituye la más infrecuente 1 .Se presentan tres pacientes con plasmocitoma solitario nasosinusal con invasión extensa a la base craneal anterior y media. Paciente 1Paciente femenina, blanca, de 57 años, con antecedentes de diabetes mellitus tipo II tratada con glibenclamida, con diplopia horizontal de 4 meses de evolución que posteriormente se tornó vertical. Al examen físico se constató una parálisis del VI nervio craneal derecho y una paresia de los nervios craneales III, IV y VI izquierdos. Se realizó una Tomografía Computarizada (TC) de cráneo simple y con administración de contraste en la cual se observó una lesión hiperdensa en la región selar que no se modificó durante la administración de

A 15 year-old patient is present with the diagnostic of a mesenchymal chondrosarcoma of the temporal bone with infiltration of the temporal muscle and with to scroll up of the temporal lobe on January 2010. She had got a temporal craniotomy a radical insensitive modulate radiotherapy and chemotherapy as adjuvant treatment.

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The removal of ethmoidal tumors with secondary extension to the cranial base and/or facial region involves a high complexity and it is associated to a high morbility. Objective: To determine the results of craniofacial surgery in patient with ethmoid extended tumors. Methods: It was carried out a traverse retrospective descriptive study. The sample was conformed by the patients intervened surgically of anterior cranial base lesions by means of a combined craneofacial surgery during the period: January of the 2009 to January of the 2012 in the National Institute of Oncology and Radiobiology with a 2 year pursuit. Descriptive statistical variables were used. Results: 20 patients were intervened. The age average was of 44,8 years. It prevail the masculine sex (65%). Nasal obstruction constitutes the most frequent presentation. Adenocarcinoma and epidermoid carcinoma constituted the most frequent malignant lesions. Inside the benign lesions prevail the inverted papiloma. The techniques more employees were the bilateral frontal craneotomy and total etmoidectomy. The most frequent complication was the cerebrospinal fluid leak. The 2 years overall survival in patients with malignant lesions was 35%. Conclusions: A high number of complications was identified but they didn't affect the survival neither the quality of life. An acceptable rate of survival was achieved in malignant lesions.

Malignant cranial base neoplasm constitutes a heterogeneous group of lesions with common seat in this localization. In the last years endonasal endoscopic approach has been more used. Methods: It was carried out a descriptive retrospective study of the database of the Service of Neurosurgery of "Hermanos Ameijeiras" Hospital between September 2009 and September 2015 with the objective of determining the results of endoscopic treatment to these lesions. Results: They were treated a total of 12 patients with wicked lesions of the cranial base inside. Six of them corresponded to anterior cranial base: 5 carcinomas (2 indiferenciate carcinoma, 2 carcinomas of scamous cells and 1 adenocarcinoma) and a metastases of renal carcinoma. Other six corresponded to cordoma (3 patients) andhematopoyetic neoplasm (2 plasmocitomas and 1 linfoma). The age average was of 51,1 years with a masculine-feminine relationship of 1,1:1. Conclusions: Surgical resection according to oncological principles can be used with endoscopic technics that in fact are associate with less morbility, better vision, betercompartiments access, nasolacrimal system and medial canthal tendon, absence of facial scar, craniectomy and brain retraction.