From 1962 to 1979, there was a dramatic change in tinea capitis infections in children in the Philadelphia area. This has been primarily due to the virtual disappearance of tinea capitis due to Microsporum organisms. This dramatic change in a common, highly infectious childhood disease is most likely due to a sudden change in hair styles, particularly in black boys, which prevents infectious spores from reaching the scalp.

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perivascular inflammatory response throughout the upper and midreticular dermis. Eosinophils were noted as a sparse component of the infiltrate. The epidermis was unremarkable.Because hydrochlorothiazide was considered an unlikely cause for this patient's drug reaction, rechallenge was performed 3 weeks later without incident and therapy was resumed. Rechallenge with fenretinide was not performed due to the severity of the drug reaction. The other four patients in this study experienced no adverse cutaneous, hepatic, or gastrointestinal effects from fenretinide administration, although two patients experienced rapidly reversible night blindness.2