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Whether marriage causes people to live longer or whether healthier people select into marriage is an open question. In this study I followed a sample of men from age 18 to first marriage and ultimately to death. Health in early adulthood was represented by height and weight around age 20. The probability of ever marrying and the conditional probability of marriage in a given time period were lower for smaller men and greater for larger men. Marriage significantly lowered mortality risk even after controlling for health in early adulthood. Thus I found support both for selection into marriage and for protective effects of marriage.

Transgenic mice containing a sheep metallothionein 1a-sheep growth hormone fusion gene exhibited low, tissue-specific basal levels of transgene mRNA expression, resulting in slightly elevated levels of circulating growth hormone that did not lead to a detectable increase in growth. After zinc stimulation, high levels of transgene mRNA expression were induced in a number of tissues; these levels correlated with increased levels of circulating growth hormone, resulting in growth increases of up to 1.5 times the levels of controls and unstimulated transgenic mice. After removal of the zinc stimulus, transgene expression and circulating growth hormone concentrations returned to basal levels. Additional evidence from the pattern of developmental expression of the transgene suggests that zinc is the main regulator of this promoter in mice. The demonstrated regulation and low basal level of expression of the sheep metallothionein 1a promoter make it a candidate for use in other mouse transgenic studies and for use in transgenic livestock, in which regulation of expression is essential.

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