Patients critically ill with coronavirus disease 2019 (COVID-19) spend significant time on mechanical ventilation and have prolonged hospitalization duration. 1 Whether these patients have immediate pulmonary and neurocognitive recovery following discharge is unknown. Methods Patients were admitted to the University of Virginia (UVA) Medical Center ICU with COVID-19 and underwent follow-up at the UVA Post-COVID-19 ICU clinic approximately 6 weeks following discharge. Lung function and exercise capacity were assessed by using spirometry, lung volumes, diffusion capacity, and the 6-min walk test. Depression, cognitive function, and insomnia were assessed by using the Patient-Reported Outcomes Measurement Information System Depression 8a-Short Score, the Quality of Life in Neurological Disorders adult cognitive function version 2.0 score, the Montreal Cognitive Assessment (MOCA) score, and the insomnia severity index. The study was approved by the UVA Institutional Review Board.

Moderate to severe OSA is associated with subclinical ILD and with evidence of alveolar epithelial injury and extracellular matrix remodeling in community-dwelling adults, an association that is strongest among normal-weight individuals. These findings support the hypothesis that OSA might contribute to early ILD.

Background: Cell shape changes during cytokinesis and chemotaxis require regulation of the actin cytoskeletal network. Dynacortin, an actin cross-linking protein, localizes to the cell cortex and contributes to cortical resistance, thereby helping to define the cell shape changes of cytokinesis. Dynacortin also becomes highly enriched in cortical protrusions, which are sites of new actin assembly.

For personal use only. Permission required for all other uses.