Eyes with OAG had a higher rate of plateau iris configurations than expected. Longitudinal studies to evaluate plateau iris height are required to determine its significance in the pathogenesis of angle-closure glaucoma.

High-speed photography can be used to evaluate the degree of corneal displacement during tonometry with a noncontact tonometer. The amount of corneal displacement is affected by the individual's IOP, age, and sex.

Failure of surgery for glaucoma is usually due to post-surgical scarring (fibrosis), a process in which fibroblasts play a prominent role. We investigated the molecular mechanisms of such scarring by examining the expression of matrix metalloproteinases and cytokines in Tenon fibroblasts isolated from rats after glaucoma surgery. Filtration surgery was performed in one eye and implant surgery in the other; and Tenon fibroblasts were isolated from the tissue surrounding the bleb after surgery. The cells were cultured and examined for the expression of matrix metalloproteinases (MMPs) by reverse transcription-polymerase chain reaction, immunoblot and gelatin zymographic analyses. Culture supernatants were also assayed for cytokines with a multiplex array. The amounts of MMP-1 and MMP-3 mRNAs and proteins were greater in cells isolated after implant surgery than in those isolated after filtration surgery, with the progression of scar formation being more complete after the former surgery. The secretion of interleukin-6 (IL-6) by cells isolated after filtration surgery was greater than that for cells isolated after implant surgery. Depletion of IL-6 by RNA interference in cells isolated after filtration surgery increased the expression of MMP-1 and MMP-3 in these cells. These results thus suggest that the expression of MMP-1 and MMP-3 in Tenon fibroblasts is regulated by IL-6 during, and may play an important role in, scar formation after glaucoma surgery.

The intraocular pressures determined using the rebound tonometer were approximately equal to those obtained using the Goldmann applanation tonometer when the rebound tonometer measurements were made with the probe perpendicular to the corneal plane, irrespective of the location, that is, at the central cornea or 2 mm from the limbus.

The low variance of the RBT measurements and the non-significant changes in the IOP when the probe of the RBT was not on the central axis indicate that the RBT is useful for animal models of glaucoma. Further studies examining its use (repeatability and reliability) in human infants whose eyes and head are usually moving are required.