The prevalence of AGA in Korean men and women was lower than that in caucasians, as recorded in the literature. Korean men tend to have more frontal hairline preservation and show a more 'female pattern' of hair thinning than caucasians. Therefore, 'female pattern' should be added to the classification of AGA.

Objective: To evaluate long-term safety and efficacy of esketamine nasal spray plus a new oral antidepressant (OAD) in patients with treatment-resistant depression (TRD). Methods: This phase 3, open-label, multicenter, long-term (up to 1 year) study was conducted between October 2015 and October 2017. Patients (≥ 18 years) with TRD (DSM-5 diagnosis of major depressive disorder and nonresponse to ≥ 2 OAD treatments) were enrolled directly or transferred from a shortterm study (patients aged ≥ 65 years). Esketamine nasal spray (28-mg, 56-mg, or 84-mg) plus new OAD was administered twice a week in a 4-week induction (IND) phase and weekly or every-other-week for patients who were responders and entered a 48-week optimization/maintenance (OP/MAINT) phase. Results: Of 802 enrolled patients, 86.2% were direct-entry and 13.8% were transferred-entry; 580 (74.5%) of 779 patients who entered the IND phase completed the phase, and 150 (24.9%) of 603 who entered the OP/MAINT phase completed the phase. Common treatment-emergent adverse events (TEAEs) were dizziness (32.9%), dissociation (27.6%), nausea (25.1%), and headache (24.9%). Seventy-six patients (9.5%) discontinued esketamine due to TEAEs. Fifty-five patients (6.9%) experienced serious TEAEs. Most TEAEs occurred on dosing days, were mild or moderate in severity, and resolved on the same day. Two deaths were reported; neither was considered related to esketamine. Cognitive performance generally either improved or remained stable postbaseline. There was no case of interstitial cystitis or respiratory depression. Treatment-emergent dissociative symptoms were transient and generally resolved within 1.5 hours postdose. Montgomery-Åsberg Depression Rating Scale total score decreased during the IND phase, and this reduction persisted during the OP/MAINT phase (mean [SD] change from baseline of respective phase to endpoint: IND, −16.4 [8.76]; OP/MAINT, 0.3 [8.12]). Conclusions: Long-term esketamine nasal spray plus new OAD therapy had a manageable safety profile, and improvements in depression appeared to be sustained in patients with TRD. Trial Registration: ClinicalTrials.gov identifier: NCT02497287

Zn2SiO4 ceramics synthesized by the conventional solid‐state method exhibited a low Q×f value, possibly due to the formation of a ZnO second phase. However, with a small ZnO reduction from the Zn2SiO4 ceramics, the ZnO second phase disappeared and grain growth occurred due to the formation of a Si‐rich liquid phase. Specimens with a large grain size exhibited an improved Q×f value. In particular, the ceramics with nominal composition Zn1.8SiO3.8 sintered at 1300°C exhibited improved microwave dielectric properties of ɛr=6.6, Q×f=147 000 GHz, and τf=−22 ppm/°C.

BaCu(B 2 O 5 ) ceramics were synthesized and their microwave dielectric properties were investigated. BaCu(B 2 O 5 ) phase was formed at 7001C and melted above 8501C. The BaCu(B 2 O 5 ) ceramic sintered at 8101C had a dielectric constant (e r ) of 7.4, a quality factor (Q Â f) of 50 000 GHz and a temperature coefficient of resonance frequency (s f ) of À32 ppm/1C. As the BaCu(B 2 O 5 ) ceramic had a low melting temperature and good microwave dielectric properties, it can be used as a low-temperature sintering aid for microwave dielectric materials for low temperature co-fired ceramic application. When BaCu(B 2 O 5 ) was added to the Ba(Zn 1/3 Nb 2/3 )O 3 (BZN) ceramic, BZN ceramics were well sintered even at 8501C. BaCu(B 2 O 5 ) existed as a liquid phase during the sintering and assisted the densification of the BZN ceramic. Good microwave dielectric properties of Q Â f 5 16 000 GHz, e r 5 35, and s f 5 22.1 ppm/1C were obtained for the BZN16.0 mol% BaCu(B 2 O 5 ) ceramic sintered at 8751C for 2 h. J ournal

Formation process and microwave dielectric properties of the R2V2O7 (R=Ba, Sr, and Ca) ceramics were investigated. Transient RV2O6 phases, which were formed at 300°∼500°C by the reaction of RCO3 and V2O5, interacted with remnant RCO3 to form the homogeneous triclinic R2V2O7 phases at 600°–700°C. The Sr2V2O7 and Ca2V2O7 ceramics sintered at 1000° and 950°C, respectively, for 10 h showed a dense microstructure with the microwave dielectric properties of ɛr=10.4–12.1, Q×f=15 200–19 520 GHz, and τf=−30.9–34.8 ppm/°C. However, the Ba2V2O7 ceramic was well sintered at 900°C for 10 h and it showed the good microwave dielectric properties of ɛr=10.1, Q×f=51 630 GHz, and τf=−26.5 ppm/°C.