269ticle by Henzler et al that the authors mention in their letter compared radiation doses of dual-energy CT and single-energy CT in more than 250 peer-reviewed studies, with Henzler et al concluding that "there is strong evidence that [dual-energy CT] imaging with [dual-source CT] is not associated with increased radiation dose levels" (2). This has been reaffirmed in the meantime by multiple studies that demonstrated equal or even lower radiation dose of a third-generation dual-source CT system (which was used in our study) and other dual-energy CT systems in comparison to single-energy CT (3,4). Thus, dual-energy CT is considered a viable and effective alternative to single-energy CT, providing reliable image quality without increased radiation dose and, often, additional diagnostic information.Furthermore, we fully agree with their opinion regarding the value of MRI as a comprehensive modality to visualize various diseases of the spine and, consequently, potential causes for lower back pain. The goal of our study was therefore not to develop a dual-energy CT technique to replace MRI, but instead to maximize the information obtained from CT that is frequently performed in clinical routine but in which lumbar disk herniation is often not reported due to technical limitations. While we are confident that dual-energy CT may also be able to depict other abnormalities that can be commonly observed with MRI in patients with lower back pain, such as bone marrow edema (5), we decided to focus our study on a direct comparison of diagnostic performance between these modalities regarding depiction of lumbar disk herniation and spinal nerve root impingement. Other potential causes of lower back pain were therefore not included but may be an interesting subject for future studies. We believe that our findings add to the growing set of dual-energy CT techniques that provide additional information in routine imaging to improve diagnosis and, ultimately, treatment.
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