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The authors report a case of very late reactivation of retinopathy of prematurity (ROP) after bevacizumab monotherapy. A female born at 630 g and 24 weeks received two bilateral treatment of bevacizumab (Avastin; Genentech, South San Francisco, CA) for aggressive posterior ROP (APROP). At 2.5 years of age, ROP reactivated in the form of tractional retinal detachment in one eye and milder reactivation in the other. Although intravitreal bevacizumab treatment is effective in inducing regression of ROP, late reactivation and retinal detachments can occur after initial extended quiescence. Due to alterations of disease progression after bevacizumab, close follow-up by peripheral fluorescein angiography and laser ablation of persistent avascular retina is recommended to prevent disease reactivation and progression to retinal detachment.

La hernia de Amyand tiene baja incidencia (0,1 a 1 %) pero, en caso de complicación, puede asociarse con una alta tasa de mortalidad. A pesar de haber sido descrita hace más de 200 años por Claudius Amyand, siguen existiendo ciertas controversias sobre su correcto tratamiento en determinadas situaciones. La práctica o la evitación de la apendicectomía en ausencia de apendicitis y la técnica para reparar el defecto herniario según el grado de contaminación de la zona, son temas tratados en el presente artículo. Ante la falta de consenso global en la literatura científica, la individualización de cada caso y el buen juicio del cirujano deben primar a la hora de decidir el tratamiento más adecuado. Se presentan dos casos clínicos que, a pesar de tratarse de la misma enfermedad, tuvieron formas de presentación, manejo y evolución dispares. Asimismo, se adjunta la iconografía de un excepcional caso de hernia de Amyand, izquierda, junto con el hallazgo de una hernia de Littré no complicada en el mismo saco herniario. Palabras clave: hernia inguinal; hernia de Amyand; hernia de Littre; apendicectomía; herniorrafia; prótesis e implantes.

Background: Sarcoidosis is an idiopathic, multi-system, granulomatous disease with well-described ocular manifestations. However, other uveitic etiologies can manifest in a similar fashion, and ocular disease may precede systemic manifestations. Definitive diagnosis requires histologic confirmation of non-caseating granulomatous inflammation. This study reports the diagnostic yield of directed biopsy of conjunctival follicles in patients with uveitis suspected to be secondary to sarcoidosis, and compares an institutional standard tissue sectioning method to a multi-plane technique. Results: A retrospective analysis was performed of all patients who underwent directed conjunctival biopsy for suspected ocular sarcoidosis. A total of eight patients were identified; all were females. Directed conjunctival biopsy was positive in three of seven patients using standard histologic processing method, a yield of 43%. Using the multi-plane technique increased the cumulative yield to 63%.

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