Our results indicate that this therapy is effective in patients with underlying diseases of primarily degenerative origin. A significant finding was that in the group of patients with arthritis, the duration and extent of pain relief were extremely short compared to the other two groups (p<0.005, U-test).

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In the course of investigations on the synthesis of new antihistaminic agents, it appeared of interest to study the effect of substituting the quantity R-Cfor the R radical (R is aryl or O heterocyclic) into compounds possessing clinical antihistaminic activity. This communication describes the synthesis and preliminary pharmacological data of a series of compounds wherein the R-Csubstitution has been made in the O antihistaminics of the ethylenediamine type.

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