Amides of Ethylenediamines. II. Substituted Cinnamides as Local Anesthetic Agents¹

Helical Encapsulation of Graphene Nanoribbon into Carbon Nanotube

“…The above results arouse our interest in the detection of the properties of GNRs, which can spontaneously fill the SWCNTs to deliver substances into the nanoscale confining space. In this simulation, we chemically attach four cinnamamide molecules, an important substance in biology and medicine, − to the GNR with a length of 246 Å. Just as shown in Figure , the cinnamamide-modified GNR gradually gets into the CNT and forms the helical configuration.…”

Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives

“…In this small series the anticonvulsant activity was observed both for compounds with low (6,8) as well as high (3,9,10) values of logP so actually the values do not correspond with the anticonvulsant activity of the tested compounds. One conclusion could be made that increased lipophilicity may be partially responsible for neurotoxicity of 9 and 10 (but not in case of compound 3).…”

“…Cinnamic acid derivatives are known to exhibit a variety of pharmacological activities, such as antimalarial [4], antifungal [5], antimycobacterial [6], anticancer [7,8], myorelaxant [9], local anesthetic [10] or tyrosinase inhibition [11]. Moreover, anticonvulsant activity was also reported among others by Balsamo et al [12,13] and more recently by Guan et al [14].…”

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

“…In addition, cinnamic acids play vital role in the synthesis of other significant compounds such as cinnamic acid analogues can be converted into vastly essential compounds including styrenes and stilbenes through decarboxylation reaction. Cinnamic acid derivatives are known to exhibit a variety of pharmacological activities, like antimalarial [2], antifungal [3], antitubercular [4], anticancer [5,6], muscle relaxant [7], local anesthetic [8] or tyrosinase inhibitor [9]. Moreover, anticonvulsant activity was also reported [10][11][12].…”