Background
Uganda has a unique set up comprised of resource-constrained economy, social-economic challenges, politically diverse regional neighborhood and home to long-standing refuge crisis that comes from long and protracted conflicts of the great lakes. The devastation of the on-going global pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is likely to be escalated by these circumstances with expectations of the impact of the disease being severe.
Materials and methods
In this study, we formulate a mathematical model that incorporates the currently known disease characteristics and tracks various intervention measures that the government of Uganda has implemented since the reporting of the first case in March 2020. We then evaluate these measures to understand levels of responsiveness and adherence to standard operating procedures and quantify their impact on the disease burden. Novel in this model was the unique aspect of modeling the trace-and-isolate protocol in which some of the latently infected individuals tested positive while in strict isolation centers thereby reducing their infectious period.
Results
The study findings show that even with elimination of all imported cases at any given time it would take up to nine months to rid Uganda of the disease. The findings also show that the optimal timing of easing of lockdowns while mitigating the possibility of re-emergence of a second epidemic wave requires avoiding the scenario of releasing too-many-too-soon. It is even more worrying that enhancing contact tracing would only affect the magnitude and timing of the second wave but cannot prevent it altogether.
Conclusion
We conclude that, given the prevailing circumstances, a phased-out lifting of lockdown measures, minimization of COVID-19 transmissibility within hospital settings, elimination of recruitment of infected individuals as well as enhanced contact tracing would be key to preventing overwhelming of the healthcare system that would come with dire consequences.
This paper develops and analyses a habitat area size dependent mathematical model to study the transmission dynamics of COVID-19 in crowded settlements such as refugee camps, schools, markets and churches. The model quantifies the potential impact of physical/social distancing and population density on the disease burden. Results reveal that with no fatalities and no infected entrants, the reproduction numbers associated with asymptomatic and symptomatic cases are inversely proportional to; the habitat area size, and the efforts employed in tracing and hospitalising these cases. The critical habitat area below which the disease dies out is directly proportion to the time taken to identify and hospitalise infected individuals. Results also show that disease persistence in the community is guaranteed even with minimal admission of infected individuals. Our results further show that as the level of compliance to standard operating procedures (SOPs) increases, then the disease prevalence peaks are greatly reduced and delayed. Therefore, proper adherence to SOPs such as use of masks, physical distancing measures and effective contact tracing should be highly enforced in crowded settings if COVID-19 is to be mitigated.
The American yam bean (Pachyrhizus spp.) is a legume crop that is exclusively used for its storage roots. The seeds are inedible due to presence of toxic rotenone. It produces high storage root yields comparable of major root crops like cassava or sweetpotato. And flower pruning more than doubles its root yield performance. Using twenty five yam bean accessions, the current study aimed to determine root yield stability and adaptability, and presence of yam bean production mega environments in Uganda. Trials were planted at three stations, Namulonge, Serere, and Kachwekano during two consecutive seasons of 2011. Fresh storage root yields were significantly different (p < 0.05) across locations with the ideal location being Namulonge (fresh storage root yield of 10.1 t ha-1), followed by Serere (8.0 t ha-1), and Kachwekano (3.1 t ha-1). Results of AMMI analysis indicated the presence of genotype-by-environment interaction for fresh storage root yield. Through AMMI estimates and GGE visual assessment, genotype 209017 was the highest yielding with mean yield of 20.7 t ha-1. Genotype 209018 with mean yield of 15.5 t ha-1 was the most stable and adapted accession in the entire discriminating environment in Uganda. From the environmental focusing plot, the six environments were grouped into two putative mega environments for yam bean production.
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