This study examined the roles of hassles, avoidant and problem-focused coping, and perceived social support as mediating the relationship between maladaptive perfectionism and psychological distress in a sample of university professors. Hassles and avoidant coping both partially mediated a strong association between maladaptive perfectionism and psychological distress. These results are discussed in terms of the need to better understand how coping styles and social support are associated with the negative impact of perfectionism on the lives of university professors. The implications of these findings for counseling practice are also explored.

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

This study examined educational experiences of families under COVID and their schooling decisions in the 2021 school year. Results from a survey of 1743 parents indicate most schools provided educational resources ranging from hardcopy packets to live online instruction. Parents were generally positive about the experience. Parents in private and charter schools reported a more positive experience than those in traditional public schools. Only a small percentage of respondents said they were going to homeschool in fall 2020, but more than a third planned to send their child to a virtual school out of concern about their child's health. KEYWORDS COVID This study examines the experiences and perspectives of parents and families with remote learning in spring 2020 during COVID-19 closures. For the latter part of the 2020 school year, parents had the primary responsibility of teaching their children at home. This presented parents with the opportunity to observe and evaluate (a) what their children were learning, (b) the ability and willingness of schools to provide educational resources to families, and (c) other educational options. This experience at remote learning may have confirmed parents' reliance on the neighborhood school, while for others it may have compelled them to consider other options. Since we are writing in August 2020, this is one of the first studies to systematically examine the educational experiences of families under COVID and what that may mean for schooling decisions in the 2020-2021 school year and beyond. Background How schools responded

Bathing creates some of the highest levels of discomfort in the lives of individuals diagnosed with dementia. The present study measured the frequency of 14 agitated behaviors during bathing in 15 elderly residents with dementia residing in a continuing care center. Each resident was observed for four sessions of two different bathing methods, the conventional tub bath and a modification of the bed bath, known as the Thermal bath. The summed frequencies of all agitated behaviors was significantly less for the Thermal bath than the tub bath. This overall effect was greater in men than women and in one particular behavior, shivering. The results suggest that for individuals with dementia the Thermal bath offers a viable alternative to the conventional tub method. Further research may clarify other parameters, such as cost effectiveness and long-term effects of the use of non-rinse cleansers for elderly individuals.

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