RESUMOThe study was conducted open with randomized two-period crossover design and a 14-day washout period. Samples were obtained over a 48-hour interval. Glimepiride concentrations were analyzed by LC-MS-MS. From the glimepiride plasma concentration versus time curves the following pharmacokinetic parameters were obtained: AUC (0-last) , AUC (0-t) , AUC (0-∞) , K e , T 1/2 , C max , and T max . Results: Geometric mean of Glimepirida/Amaryl ® 4 mg was 102.35% for AUC (0-t) , 102.35% for AUC (0-∞) and 99.31% for C max . The 90% CI was 92.62-109.55%; 95.62-109.55% e 88.60-111.32%, respectively. Conclusion: Since the 90% CI for both C max , AUC (0-t) , and AUC (0-∞) were within the interval of 80-125%, it was concluded that both formulations were bioequivalent, according to both the rate and extent of absorption.
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