RESUMOO Alzheimer é uma doença neurodegenerativa caracterizado pelo comprometimento cognitivo comumente associado a transtornos do humor, os quais desencadeiam reações depressivas, comprometem o desempenho mental e a funcionalidade. O objetivo do presente estudo foi verificar os efeitos do L-triptofano e analisar o comportamento motor em modelos experimentais com depressão decorrente do processo de Alzheimer. A amostra foi composta por 40 ratos da linhagem wistar divididos igualmente em dois grupos, 20 animais tratados com L-triptofano e 20 animais pertencentes ao grupo controle. Ambos os grupos receberam treinamento da memória espacial no later water maze e foram submetidos à cirurgia estereotáxica para indução demencial. Verificou-se através do labirinto aquático de Morris que o grupo tratado obteve atividade para memória espacial melhor do que o grupo controle. O tratamento com L-triptofano demonstrou melhor benefício na memória reativa. Palavras-chave: Doença de Alzheimer. Depressão. Serotonina. Triptofano. ABSTRACTAlzheimer is a neurodegenerative disease characterized by cognitive impairment normally associated with mood disorder, which triggers depressive reactions and compromises mental performance and functionality. The objective of the present study was to verify the effect of L-tryptophan and analyze the motor behavior in experimental models with depression caused by the Alzheimer process. The sample was composed by 40 wistar rats divided equally in two groups, 20 animals treated with L-tryptophan and 20 animals from control group. Both groups received spatial memory training in water maze and were submitted to stereotaxic surgery to induce dementia. It was verified through Morris water maze that the treated group obtained a better spatial memory activity than the control group. The treatment with L-tryptophan demonstrated benefit in reactive memory. Keywords: Alzheimer Disease. Depression. Serotonin. Tryptophan. IntroduçãoA doença de Alzheimer (DA) é uma patologia neurológica, degenerativa, lenta e gradativa, que inicialmente afeta a memória episódica e é mais comum após a quinta década de vida 1,2 . Essa demência corresponde a 60% dos casos de comprometimento cognitivo progressivo em idosos 3 , onde o acometido manifesta dificuldades na aquisição de novas tarefas, em memorizar, decidir, agir, alimentar-se e no estágio mais avançado apresenta um estado vegetativo, incluindo alterações no ciclo circadiano, modificações comportamentais, sintomas psicóticos, inabilidade para caminhar, falar e realizar o autocuidado 2,4 . Os mecanismos da neurodegeneração atingem primeiramente as estruturas do lobo temporal medial, entre eles o hipocampo e o giro parahipocampal que são estruturas fundamentais para a memória. Posteriormente a degeneração afeta outras regiões do neocortex associativo, comprometendo a cognição. Isto se deve a uma anormalidade nas placas senis e a emaranhados neurofibrilares formados por uma modificação na proteína precursora de amiloide e ao hipercolapso do citoesqueleto neuronal derivados d...

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Introduction: Musculoskeletal symptoms are affections, with or without degeneration of the tissues, and may present in various forms and be associated with multiple symptoms. At the moment its etiology is multifactorial and the pathological picture shows social relevance due to its scope and magnitude. Objective: The objective of this study was to evaluate and compare the prevalence of musculoskeletal symptoms in academics of full-time and part-time (nighttime) courses at UNICENTRO. Methods: The study counted on 120 students of both courses and for the selection of the individuals was used the stratified sampling method. The Nordic questionnaire for musculoskeletal symptoms (NMQ) and Visual Analogue Scale (VAS) questionnaire were used as a form of pain identification. Results: Observing the results obtained from the NMQ, it was observed a high prevalence of symptoms in the analyzed students, being 49% in Biological Sciences and 44.8% in Physiotherapy, highlighting the region of the vertebral column, being lumbar (9.42%) in academics of Physiotherapy and thoracic region (9.14%) in academics of Biological Sciences, also noted high involvement in multiple regions (53.9%). Furthermore, it was observed the presence of mild pain trough VAS (3.78 ± 2.38). Conclusion: It was concluded that the most affected region was the spine, specifically the lumbar and thoracic. Thus, it is assumed that biomechanical overload is responsible for this finding. Thus, preventive and ergonomic measures and health promotion should be stimulated among young students, but for this purpose further studies are needed.

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive and incapacitating decay of cognitive, neuropsychiatric, and behavioral manifestations. L-tryptophan is the precursor amino acid of serotonin, which is a neurotransmitter responsible for mood balance and the sense of well-being and can be administered in the form of nanoparticles. Objective: This study analyzed the effectiveness of L-tryptophan nanoparticles and L-tryptophan on behavioral physiological alterations resulting from AD in animal models. Methods: The sample consisted of 50 Rattus norvegicus rats, divided in 10 groups with 5 animals each: one negative control (NC), three positive control groups (C3, C7, and C21), three groups treated with L-tryptophan nanoparticles (T3N, T7N, and T21N) at the concentration of 1.5 mg, and three groups treated with L-tryptophan (T3L, T7L, and T21L) at the concentration of 1.5 mg. The rats underwent stereotactic surgery to induce AD through the injection of amyloid beta-amyloid peptide1-42 in the intracerebroventricular region. All rats were submitted to pre- and post-surgery and post-treatment motor behavior evaluation through the Later Water Maze (LWM) and elevated cross-labyrinth (ECL). Histological analysis was performed to verify the presence of senile plaques, and the statistical analysis used the unpaired T-test. Results: Significant intergroup differences were observed in some of the evaluated parameters between treated and untreated groups. Conclusion: It was concluded that the treatment with L-tryptophan nanoparticles was beneficial to improve behavioral reactions in the Alzheimer's model.