Objective: To determine the frequency of complications in patients with intrahepatic cholestasis of pregnancy. Study Design: Descriptive Case Series. Setting: Department of Obstetrics & Gynecology, Shahida Islam Medical College, Lodhran. Period: July 2019 to December 2020. Material & Methods: A total of 141 patients with intrahepatic cholestasis of pregnancy of age 18 to 40 years were included. Patients with multiple pregnancies, history of alcohol intake, CR and preexisting chronic liver disease were excluded. All women were followed till delivery (gestational age ≤ 41 weeks) and feto-maternal outcome i.e. postpartum hemorrhage, cesarean section, APGAR score <7 at 5 minutes, low birth weight, prematurity, meconium stained liquor and intrauterine fetal death (yes/no) was noted. Results: Feto-maternal outcome was as follows; postpartum hemorrhage in 18 (12.77%), cesarean section in 47 (33.33%), preterm birth in 34 (24.11%), APGAR score <7 at five minutes in 13 (9.22%), meconium stained liquor in 45 (31.91%) patients, low birth weight in 14 (9.93%) and Intra-uterine fetal death in 11 (7.80%) patients. Conclusion: Our study concluded that we should develop some serious recommendations for these high risk patients in our routine practice. It will reduce the morbidity and mortality related to this high risk condition.

Aim: To compare the efficacy of letrozole and clomiphene citrate in women having anovulatory infertility. Study design: Randomized Controlled Trial. Place and duration of study: 16th October 2020 to 15th September 2021 in Department of Obstetrics & Gynecology, Shahida Islam Medical Complex Lodhran. Methods: In our study 112 patients between ages 18 to 40 years with anovulation were included. Patients having H/O previous pelvic surgery, raised prolactin and TSH levels were excluded. These women were divided into02 groups i.e. Group A (clomiphene citrate) & Group B (letrozole), by lottery method and the effectiveness was noted in both groups. Results: Mean age of women in group A was 24.53±6.12 years and in group B was 25.37±6.33 years. Majority women included in our study, 78(69.64%) were between ages 18 to 30 years. Duration of infertility was 3.28±2.11 years. Mean infertility duration in group A was 3.63±2.10 years and in group B was 3.79±2.14 years. The efficacy of drug shownin Group A was 9(8.03%) while in Group B was 18(16.07%) (p-value = 0.005). Conclusion: We concluded from this study that letrozole is proved to be more efficacious than clomiphene citrate in anovulatory infertility. Keywords: Anovulation, Infertility, Letrozole, Clomiphene Citrate, Conception Rate