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Comprehensive autopsy studies (1, 2) have disclosed that enlargement of the viscera, including the heart, lungs, kidneys, pancreas, adrenals, and particularly the liver, is a prominent and consistent feature of acromegaly. The detailed structural changes responsible for visceromegaly in patients with this disease are poorly understood. Studies of the functional alterations of the hypertrophied organs are few and have been focused almost exclusively on the kidneys. Increased renal plasma flow, glomerular filtration rate, and proximal tubular functions have been demonstrated (3-5). It seemed reasonable, therefore, to expect that blood flow and excretory function of the liver might also be augmented.Precise appraisal of liver size by clinical examination alone is difficult; furthermore, evaluation of hepatic hyperfunction cannot be made with routine liver function tests. The introduction of methods for measurement of splanchnic blood flow and volume (6, 7) and for estimation of sulfobromophthalein (BSP) kinetics (8, 9) has made quantitative determination of hepatic function possible. Correlation of function with hepatic size is feasible owing to the development of techniques for quantification of "liver volume" (10).The results of such studies, carried out in 11 pa-

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