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Background: Phototherapy has been a mainstay in the treatment of mycosis fungoides (MF). However, the recent findings of UV-induced p53 mutations in advanced MF suggest that phototherapy may contribute to disease progression. Objective: The objective of this study was to evaluate the effect of phototherapy on the time to tumor progression and overall survival in MF. Materials and methods: Retrospective analysis of patients seen at the University of Pittsburgh Cutaneous Lymphoma Clinic from 1979 to 2016. Results: 345 patients with MF were identified. 258 (74.8%) were diagnosed at stage IA or IB. 43 out of 258 (16.6%) progressed to tumor stage. Before tumor development, 30 out of 43 (69.8%) patients received phototherapy, and 13 (30.2%) did not. Patients who received phototherapy had a longer median time to tumor progression than those who did not: 3.5 years (interquartile range = 1.9 – 5.7) versus 1.2 years (0.2 – 2.3) (p =0.001). Patients who received phototherapy also survived longer: 6.9 years (interquartile range = 4.3 – 9.5) versus 3.8 years (3.0 – 4.5) (p = 0.014). Limitations: Limited information on specific phototherapy start dates, durations, and treatment protocols. Conclusions: The therapeutic effects of phototherapy, with longer times to tumor progression and increased overall survival, appear to outweigh its potential adverse effects.

Purpose Application of adhesive tape to the eyelids during general anesthesia decreases the risk of corneal abrasion but may increase the risk of eyelid injury. The aim of this study was to determine if there is a difference in eyelid erythema when covering the eyelid with either Tegaderm TM or an EyeGardÒ. Methods We conducted a prospective, randomized, double-blind, split-face study of patients undergoing general anesthesia at an urban tertiary care academic medical centre. Each patient was randomized to having one eyelid covered with Tegaderm and the other with EyeGard. Photographs were taken prior to extubation and evaluated by three dermatologists. The primary outcome was the incidence of postoperative eyelid erythema. Secondary outcomes included the incidence of corneal abrasion and patient satisfaction.

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