This case report describes a 52-y-old male patient who, one week after influenza vaccination, presented with abdominal symptoms: pain in the right epigastrium followed by liver dysfunction and pyrexia, as well renal failure, muscles pain and consciousness disorders. Immune-complex-like disease and Enterobacter cloacae sepsis due to cholelithic cholecystitis were diagnosed. In this case, a correlation between vaccination and immune complex-like-disease was suspected based on the onset of symptoms a few days after vaccination and clinical improvement after plasmapheresis. The etiopathogenesis of immune-complex-like disease in this case possibly could relate to the similarity of the vaccine antigens and E. cloacae antigens as well a genetic predisposition.

The authors present a case of a male who, a week after influenza vaccination presented with abdominal symptoms-pain in the right epigastrium followed by pyrexia, muscle pain, disturbed liver and kidneys function as well as consciousness disorders. Immune complex-like disease and Enterobacter cloacae sepsis due to cholelithic cholecystitis were diagnosed. In this case, the suspected correlation between vaccination and immune complex-like disease resulted mainly from two reasons-the onset of symptoms after few days after vaccinations and clinical improvement after plasmaferesis. In etiopathogenesis of this specific case the similar immunogenicity of vaccine compounds and Enterobacter cloacae antigens, and patient genetic predisposition should be considerated.