Hybridization of metal-organic frameworks (MOFs) and polymers into composites yields materials that displaythe exceptional properties of MOFs with the robustness of polymers.H owever,t he realization of MOF-polymer composites requires efficient dispersion and interactions of MOF particles with polymer matrices,which remains asignificant challenge.Herein, we report asimple,scalable,bench-top approach to covalently tethered nylon-MOF polymer composite materials through an interfacial polymerization technique. The copolymerization of am odified UiO-66-NH 2 MOF with ag rowing polyamide fiber (PA-66) during an interfacial polymerization gave hybrid materials with up to around 29 weight percent MOF.T he covalent hybrid material demonstrated nearly an order of magnitude higher catalytic activity for the breakdown of achemical warfare simulant (dimethyl-4nitrophenyl phosphate,D MNP) compared to MOFs that are non-covalently,p hysically entrapped in nylon, thus highlighting the importance of MOF-polymer hybridization.