Injuries and lack of motivation are common reasons for discontinuation of running. Real-time feedback from wearables can reduce discontinuation by reducing injury risk and improving performance and motivation. There are however several limitations and challenges with current real-time feedback approaches. We discuss these limitations and challenges and provide a framework to optimise realtime feedback for reducing injury risk and improving performance and motivation. We first discuss the reasons why individuals run and propose that feedback targeted to these reasons can improve motivation and compliance. Secondly, we review the association of running technique and running workload with injuries and performance and we elaborate how real-time feedback on running technique and workload can be applied to reduce injury risk and improve performance and motivation. We also review different feedback modalities and motor learning feedback strategies and their application to real-time feedback. Briefly, the most effective feedback modality and frequency differ between variables and individuals, but a combination of modalities and mixture of real-time and delayed feedback is most effective. Moreover, feedback promoting perceived competence, autonomy and an external focus can improve motivation, learning and performance. Although the focus is on wearables, the challenges and practical applications are also relevant for laboratory-based gait retraining.

Thevetia peruviana is a small tree that produces several compounds with pharmaceutical application, among which peruvoside could be highlighted. However, these compounds are produced in low concentration in the plant, making it important to develop strategies such as plant cell culture and elicitation to obtain higher quantities of the desired product. In this work, cell suspension cultures of T. peruviana were established in four different culture media: Murashige-Skoog (MS), half MurashigeSkoog (half MS), Schenk-Hildebrandt (SH), and Gamborg (B5) to study their effect on cell growth. Cell growth kinetics were studied in SH medium, and the extracellular peruvoside production during the culture time was determined. The best culture medium for the establishment of cell suspension cultures was MS with a growth index of 3.17±0.2 g g −1 inoculum. The cell growth kinetics showed the four characteristic growth phases of a cell culture (lag, exponential, stationary, and death), and during none of these phases was it possible to observe peruvoside production. The elicitor effect of methyljasmonate (MeJ) was studied in cell suspension cultures established in SH medium. The effect of MeJ concentration and the time in which it should be applied were determined. The best results were obtained at a concentration of 100 mg l −1 of MeJ applied at the beginning of the culture, which induced a peruvoside production of 8.93 mg l −1 medium. The current results are the first report of an in vitro peruvoside production system.

The lack of good quality planting material of farmers' cassava varieties, produced locally and at low cost, is a major constraint limiting the expansion of cassava production in Colombia. This article describes the adaptation of conventional cassava propagation to a low-input scheme for rural tissue-culture multiplication, developed and run by small, resource-poor farmers (referred in this article as an informalfarmers' seed production system). Developed through a two-phase participatory process by a group of women farmers, a non-governmental organization and International Center for Tropical Agriculture scientists in a farmers' community in the hillsides of southern Colombia, the project resulted in alternative, economical and readily available sources of tissue-culture material and equipment. Rates of multiplication achieved with the system were as high as with conventional tissue-culture procedures.

There is a great deal of interest worldwide in serving people with diverse abilities and needs, especially in the fi eld of education. This implies a commitment to inclusion, empowerment and creating opportunities in a range of sectors. The deaf pose a considerable challenge to any proposal for inclusion and social integration, because their diffi culty aff ects communication. The purpose of this study is to contribute to theoretical refl ection on the development of communication tools that give the

We propose a two-stage algorithm for generating Delaunay triangulations in 2D and Delaunay tetrahedra in 3D that employs near maximal Poisson-disk sampling. The method generates a variable resolution mesh in 2-and 3-dimensions in linear run time. The effectiveness of the algorithm is demonstrated by generating an unstructured 3D mesh on a discrete fracture network (DFN). Even though Poisson-disk sampling methods do not provide triangulation quality bounds in more than two-dimensions, we found that low quality tetrahedra are infrequent enough and could be successfully removed to obtain high quality balanced three-dimensional meshes with topologically acceptable tetrahedra.