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Leiomyosarcoma of the ovary is a rare disease, with aggressive behavior and poor prognosis, which mainly occurs in postmenopausal women. Surgery is the cornerstone of treatment, while the role of chemotherapy and radiotherapy is still not clear because substantial data is lacking. This paper presents the case of an adult woman who is diagnosed with primary leiomyosarcoma of the left ovary, and who receives a surgical approach and adjuvant treatment with chemotherapy currently achieving 20 months free from disease.

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The use of erlotinib throughout pregnancy has not been previously reported. We present the case of a 40 yearold female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150 mg once daily. After two and a half months of treatment a fourteen-week pregnancy was documented, and after informing on fetal risks secondary to erlotinib use and maternal risks secondary to treatment withholding, she decided to continue with treatment under clinical surveillance by both the oncology and obstetrics clinics. At thirty-three weeks gestation a live born 1600 g female was born by caesarean section without evidence of congenital malformations. Imaging assessment after eight months of treatment showed complete bone and central nervous system response and partial lung and mediastinal response. The patient is currently undergoing the 11th month of treatment and is asymptomatic, the baby is 4 months old and is in good health.

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