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Background:Urinary incontinence,involuntary urination,is any leakage of urine.It can be a common and distressing problem,which may have a profound impact on quality of life.Different risk factors are associated with urinary incontinence. Diabetes and arthritis are the major risk factors of urinary incontinence. Free radicals are produced during inflammation and hyperglycemia state as a result oxidative stress occurs during diabetes and arthritis. Aim and objectives:The aim of the present study was to evaluate the activity of two oxidative stress marker such as glutathione reductase and glutathione peroxidase in diabetes and arthritis patient risk of UI. Materials and methods:The study protocol and all recruitment materials were approved by the ethical board and study was carried out 40 diabetic,40 arthritic patients and 20 healthy control,taken from