Two new phenylethanoids, basalethanoid A (1) and B (2), and one new ceramide, basalamide A (3), together with eleven known compounds (4 - 14) were isolated from theMeOH extract of the stem barks of Basalmocitrus cameroonensis. The structures of all compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral (EI and ESI) data, chemical reactions, and comparison with previously known analogs. Compounds 1, 2, 5, and 7 - 10 demonstrated a strong inhibition on reactive oxygen species (ROS) production in the oxidative burst activity of whole blood on activation with serum opsonized zymosan in the range of IC50 = 0.06 - 12.30 μg mL−1.

A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.

Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The alkaloids 9-11 were isolated for the first time from this genus. All compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes using the paper disk agar diffusion assay. The agar diffusion test gave only low antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1-4 and 11 exhibited a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC(50) = 2.6-6.5 µM, while low cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3 was observed with IC(50) values ranging from 22.9 to 39.4 µM.

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Lipids U 0750Bioactive Phenylethanoids and Coumarines from Basalmocitrus cameroonensis.-New phenylethanoids, basalethanoid A (Ia) and B (Ib), and the new ceramide basalamide A (II) are isolated from the stem barks of Basalmocitrus cameroonensis along with eleven known compounds. Compounds (I) show a strong inhibition on reactive oxygen species production in the oxidative burst activity of whole blood on activation with serum opsonized zymosan. -(WANSI*, J. D.; BAVOUA, J. L. D.; HAPPI, E. N.; DEVKOTA, K. P.; LENTA, B. N.; MESAIK, M. A.; CHOUDHARY, M. I.; FOMUM, Z. T.; SEWALD, N.; Z. Naturforsch., B: Chem. Sci. 64 (2009) 4, 452-457; Dep. Chem., Fac. Sci., Univ. Douala, Douala, Cameroon; Eng.) -H. Toeppel 34-199