Introduction: This observational study was done to study the patients having metabolic syndrome with chronic obstructive pulmonary disease (COPD). Methodology: A cross-sectional observational study was done which included all the patients having COPD by convenience sampling presented at the Respiratory Medicine Department in Acharya Vinoba Bhave Rural Hospital, a tertiary hospital in Sawangi (Meghe), Wardha, India, from November 2021 to January 2022. The patients having metabolic syndrome as per definition were studied, and appropriate statistical tests were applied. Observation and Results: A total of 124 patients were studied in total out of which 40 patients had metabolic syndrome. Out of 124 patients studied, 70 were females and 54 were males. Almost half of the patients were above 70 years of age and above. Out of 40 patients having metabolic syndrome, 18 were females and 22 were males. Conclusion: The study concluded that metabolic syndrome was present in a significant population of COPD; hence, with appropriate interventions, the morbidity and mortality of COPD may be reduced by reducing the occurrence of metabolic syndrome.

This study investigated the association and predictive value of biomarkers in hospitalized patients with SARS-CoV-2 infection. Coronavirus disease (COVID) infection has been linked to a significant hyperinflammatory immune response described as a “cytokine storm,” which results in organ deterioration and damage. Several studies have shown that cytokine levels, notably interleukin 6, can be used as indicators of COVID-19 disease severity. This hospital-based cross-sectional study was conducted in DMIMS Medical College, Sawangi-Meghe, Wardha, from March 2020 to April 2020. The study population was confirmed adult cases of COVID-19 admitted to the hospital during the study period. A positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction or rapid antigen test from a nasopharyngeal swab or other respiratory sample was defined as a confirmed SARS-CoV-2 case. A purposive sampling technique was used and a total of 100 study subjects were enrolled for the study. Our study discovered a link between hematological, coagulation, and inflammatory indicators and infection severity. However, whether these indicators have a mechanistic or causative role in illness progression has to be investigated further.

Tuberculosis (TB) is one of the most common infectious diseases in developing countries throughout the world. According to the WHO, there has been a rise in the number of cases of drug-resistant (DR) TB in recent times. Tubercular pleural effusion is challenging to diagnose given the low bacillary load and frequently negative stains for acid-fast bacilli (AFB) on Ziehl-Neelsen (ZN) staining. We present a case of successful diagnosis and management of primary extra-pulmonary multidrug-resistant (MDR) tubercular pleural effusion after being misdiagnosed from outside as drug-sensitive extra-pulmonary TB. Initial tests revealed exudative effusion with raised adenosine deaminase (ADA) levels, therefore the patient was started on conventional anti-tubercular therapy with isoniazid (H), rifampicin (R), pyrazinamide (Z), and ethambutol (E), but the patient did not improve in spite of regular treatment for two months, which warranted further investigations. Therefore Xpert® MTB/R assay (Cepheid Inc., Sunnyvale, USA), line probe assay (LPA), and drug sensitivity testing (DST) of the pleural fluid were sent, which were suggestive of R-and H-resistant tubercular effusion. The patient was started on an oral bedaquiline-containing regimen as per the WHO guidelines and the patient showed considerable improvement on follow up.

The clinical syndrome described in the literature as "Pickwickian syndrome" is characterized by a combination of sleep-disordered breathing, obesity, and daytime hypercapnia; the condition is also known as obesity hypoventilation syndrome (OHS). This syndrome is a diagnosis of exclusion after every other possible etiology is ruled out. Patients can present both with an exacerbation of or a chronic state of progressive dyspnea. In this report, we describe the case of a 62-year-old morbidly obese female with a BMI of 42 Kg/m 2 , who presented with progressively worsening breathlessness. An arterial blood gas (ABG) analysis revealed severe hypoxia with hypercarbia. A sleep study [polysomnography (PSG)] of the patient was performed, which revealed an apnea-hypopnea index (AHI) of 58.2, and the patient was diagnosed as having OHS after all other possible cardiorespiratory etiologies were ruled out. The patient was promptly managed with non-invasive ventilatory (NIV) support along with supportive management and was prescribed overnight NIV and subsequently discharged in stable condition.