Platonia insignis Mart, Clusiaceae, known as bacuri, is a species native to Brazil that, in studies with extract of the seed of its fruit, showed antioxidant activity against free radicals. Products with such properties may be of great importance in the treatment of peptic ulcers since this pathology may be associated with the inflammatory process caused by the action of free radicals. Cyclodextrins are molecules capable of forming inclusion complexes with other molecules, affecting their physicochemical properties and improving their pharmacokinetic characteristics. Thus, this work aimed to produce, characterize, and evaluate the gastroprotective effect of the inclusion complex of β-cyclodextrin (β-CD) with the bacuri seeds hexanic extract (BSHE). In the characterization of the inclusion complex, an apparent stability constant (Kc) of 416 mol/L was obtained in the solubility study; the BSHE:β-CD m/m (g) complexation ratios at 1:9, 2:8, and 3:7 were 5.51%, 21.46%, and 20.11%, respectively. The formation of the BSHE:β-CD inclusion complex was observed by FTIR technique, indicating the disappearance of bands characteristic of BSHE (2960 cm−1 and 1755 cm−1) when in the complex, compared to the spectra of pure BSHE or in physical mixture with β-CD, and by X-ray diffraction, which indicated a loss of crystallinity, typical signals of pure β-CD, and presentation of intense amorphization, characteristic of BSHE, incorporated in the β-CD pockets. In the evaluation of gastroprotective activity, through absolute ethanol-induced gastric lesions in mice, both BSHE and BSHE:β-CD reduced gastric lesions, with 100 mg/kg dose of the complex having the greatest gastroprotective effect. BSHE:β-CD was also able to reduce gastric lesions from ischemia and reperfusion, with the 50 mg/kg dose being the most effective. BSHE:β-CD, also at this dose, reduced the MDA levels of the gastric mucosa, indicating a possible antioxidant activity in its gastroprotective effect. Thus, it was concluded that inclusion complex formation between β-CD and BSHE is possible, and that this formulation enhanced the gastric protective activity.

Purpose: to evaluate the dressing material costs provided to patients under home care for the public service of Brazilian health relate with the socio-demographic profile, the type of wound, and associated comorbidities.Design: Documentary, cross-sectional study with a quantitative approach. Subjects and setting:The sample consisted of 334 medical records filed by the public health service that provided materials and covers to patients with wounds registered in primary care in the city of Teresina, state of Piauí, Brazil, to perform dressing in domicile.Methods: Utilization of a semi-structured instrument for collecting data, containing information about the sociodemographic profile, comorbidities, number of wounds and cost of materials dispensed. In the inferential analysis, we used the Kruskal-Wallis test and the MannWhitney test to compare the total costs of treatment.Results: There was a predominance of men (65.5%), elderly (49.1%), with a prevalence of pressure ulcers (44.6%), in which the main cover was the collagenase (53.9%) followed by essential fatty acids (41.1%).

Analisa experiências extensionistas do Humanismo Caboclo, entre 2014 e 2015, a partir de trabalhos educativos de duas estudantes do curso de Pedagogia junto às suas comunidades, em municípios do estado do Piauí. A proposta extensionista, inspirada no pensamento de Paulo Freire (1987; 1996; 2011), fomentou as caminhadas de organização e luta social dos grupos dos quais fazem parte as estudantes (um grupo de jovens e uma associação ambientalista) em diálogo com o suporte teórico sobre educação popular. Seu foco é compreender as trajetórias construídas pelos coletivos: ações, objetivos, estratégias e processos. Paralelamente, discute um sentido para extensão universitária que supera o assistencialismo social e a educação instrumentalizadora.