In health the most frequent researches are done in the form of observational studies. In this type of scientific research the researchers did not interfere with the phenomena under study, only observed in a systematic and standardized manner, collecting and recording information, data or materials that spontaneously occur at a particular time of the health-disease process, or along its natural evolution, and then proceed with its description and/or analysis. In observational studies normally four types of study design are used: case series studies, cross-section studies, case-control studies and cohort studies. Thus, cross-sectional studies are very useful in descriptive studies when used in studies that are proposed to be analytical, the results must be interpreted by researchers with good experience in that specific field of knowledge, using a lot of caution and common sense.

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Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms.

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