Objective:To assess the physiopathology of olfactory function loss (OFL) in COVID-19 patients, we evaluated the olfactory clefts on MRI during the early stage of the disease and one month later.Methods:This was a prospective monocentric case-controlled study. Twenty SARS-CoV2-infected patients with OFL were included and compared to 20 age-matched control healthy subjects. All infected patients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at one-month follow-up.Results:At the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 +/- 2.7 (range 0–8), and MRI displayed a complete obstruction of the OC in 19 out of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At one month follow-up, the olfactory score had improved to 8.3 +/- 1.9 (range 4–10) in patients, and only 7 out of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC (p=0.004).Conclusion:OFL in SARS-CoV2-infected patients is associated with a reversible obstruction of the OC.

Objectives: To assess the efficacy of local intranasal treatment with budesonide (nasal irrigation), in addition to olfactory rehabilitation, in the management of loss of smell in COVID-19 patients without signs of severity and with persistent hyposmia 30 days after the onset of symptoms. To search for an association between the presence of an obstruction on MRI and the severity of olfactory loss, at inclusion and after 30 days of treatment.

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