We performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.

The most common histologic type of lung cancer among the patients in this study was squamous cell carcinoma (n = 12). The most common clinical presentation was abdominal pain (n = 15). A total of 31 lesions were visualized on CT scans, involving the stomach (n = 3), small bowel (n = 26), and colon (n = 2). The metastatic lesions were seen on CT scans as wall thickening in 14 cases, an intraluminal polypoid mass in 14 cases, and an exophytic mass in three cases. The lesions exhibited isoattenuation in 19 cases, hypoattenuation in seven cases, and hyperattenuation in five cases. Complications included intussusception in seven cases, perforation in six cases, and obstruction in four cases.